SAB3500496

Anti-SIRT5 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-NAD-dependent deacetylase sirtuin-5, Anti-SIR2L5, Anti-Sirtuin 5
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: chicken
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: human, mouse
• técnica(s): indirect ELISA: suitable; western blot: suitable
• nº de adesão NCBI: NP_036373
• nº de adesão UniProt: Q9NXA8
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SIRT5(23408)

Descrição

Descrição geral

SIRT5 (Sirtuin 5) is a mitochondrial matrix protein belonging to the class III of the sirtuin family. It is localized inside the mitochondria and within the cytosol and nucleus. The protein is widely expressed in the brain, heart, liver and kidney. It is composed of very short amino and carboxyl terminal sequences flanking region with the conserved, catalytic sirtuin center domain.[1]

Imunogênio

SIRT5 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human SIRT5.

Aplicação

Anti-SIRT5 antibody produced in chicken is suitable for western blot and indirect ELISA.

Ações bioquímicas/fisiológicas

SIRT5 (Sirtuin 5) is associated with metabolism and aging process. It has been reported in a study that SIRT5 influences urea cycle pathway by NAD-dependent deacetylation and subsequent activation of carbamoyl phosphate synthetase 1 (CPS1), which plays a vital role in the initial step of urea cycle for the detoxification and removal of ammonia. In non-small cell-lung cancer cells. SIRT5 contributions have also been observed for the cancer cell growth and drug resistance. Study shows that SIRT5 may possess oncogenic property.[1]

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500496.

forma física

Supplied in PBS with 0.02% sodium azide.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable