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SAB3500181

Sigma-Aldrich

Anti-ADAM10 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Sinônimo(s):

Anti-KUZ

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100 μG
R$ 4.122,00

R$ 4.122,00


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Um anticorpo recombinante, sem conservantes, está disponível para seu alvo. Tente ZRB2367


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100 μG
R$ 4.122,00

About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

R$ 4.122,00


Check Cart for Availability
Um anticorpo recombinante, sem conservantes, está disponível para seu alvo. Tente ZRB2367

fonte biológica

rabbit

Nível de qualidade

conjugado

unconjugated

forma do anticorpo

IgG fraction of antiserum

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

peso molecular

predicted mol wt 85 kDa

reatividade de espécies

human

técnica(s)

immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ADAM10(102)

Descrição geral

ADAM metallopeptidase domain 10 or A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein which is widely distributed. It consists of an amino-terminal signal sequence, a prodomain, a metalloprotease domain, a disintegrin domain, a cysteine-rich region, a transmembrane region and a cytoplasmic tail. The gene encoding this protein is localized on human chromosome 15q21.3.

Imunogênio

ADAM10 antibody was raised against a peptide corresponding to amino acids 732 to 748 of human ADAM10. This sequence is identical to those of bovine and rat origins and differs from that of mouse ADAM10 by one amino acid (2,4).

Ações bioquímicas/fisiológicas

ADAM metallopeptidase domain 10 (ADAM10) activates Notch proteins and has a role in embryonic development. It functions as a molecular scissor and cleaves the extracellular domains of proteins. The protein is a therapeutic target for a variety of diseases and malignancies.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500181.

forma física

Supplied in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Natalia V Yunusova et al.
Clinica chimica acta; international journal of clinical chemistry, 494, 116-122 (2019-03-25)
Metalloproteinases and their extracellular matrix metalloproteinase inducer (EMMPRIN) play an essential role in the regulation of signaling from growth factors receptors and adhesion molecules, cell motility and extracellular matrix degradation. The aim of the study was to evaluate the relationship
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International journal of molecular medicine, 43(6), 2303-2318 (2019-04-25)
Down syndrome (DS) is caused by the presence of part or all of a third copy of chromosome 21. DS is associated with several phenotypes, including intellectual disability, congenital heart disease, childhood leukemia and immune defects. Specific microRNAs (miRNAs/miR) have been

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