SAB1305451

ANTI-USP51 (CENTER) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Deubiquitinating enzyme 51, USP51, Ubiquitin carboxyl-terminal hydrolase 51
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 79756 Da
• reatividade de espécies: human
• técnica(s): western blot: 1:1000
• nº de adesão NCBI: NP_958443.1
• nº de adesão UniProt: Q70EK9
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... USP51(158880)

Descrição

Descrição geral

Ubiquitin specific peptidase 51 (USP51) encodes a deubiquitylating enzyme. USP51 is predominantly expressed in prostate, brain, lung, aorta and kidney. In human chromosome, the gene USP51 is localized on Xp11.

Ações bioquímicas/fisiológicas

Ubiquitin specific peptidase 51 (USP51) in response to DNA damage deubiquitylates histone H2A at Lys13,15 (H2AK13,15ub) present at DNA double-strand breaks (DSBs) to maintain genome integrity. High expression of USP51 suppresses ionizing radiations induced damage on p53-binding protein 1(53BP1) and breast cancer type 1 susceptibility protein (BRCA1). Cells depleted with USP51 show an increase in G1 phase cells and decrease in S-phase cells and hence it is required for cell cycle progression. USP51 deubiquitinase zinc finger E-Box binding homeobox 1)(ZEB1) and stabilizes its expression, especially in breast tumour cells.

forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable