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S5272

Sigma-Aldrich

Sulfanitran

~85%

Sinônimo(s):

N4-Acetyl-N1-(4-nitrophenyl)sulfanilamide

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About This Item

Fórmula empírica (Notação de Hill):
C14H13N3O5S
Número CAS:
122-16-7
Peso molecular:
335.34
Beilstein:
2952955
Número MDL:
MFCD00024598
Código UNSPSC:
51101500
ID de substância PubChem:
24899645

Ensaio

~85%

forma

powder

cor

yellow to greenish yellow

espectro de atividade do antibiótico

neoplastics

Modo de ação

enzyme | interferes

cadeia de caracteres SMILES

CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C14H13N3O5S/c1-10(18)15-11-4-8-14(9-5-11)23(21,22)16-12-2-6-13(7-3-12)17(19)20/h2-9,16H,1H3,(H,15,18)

chave InChI

GWBPFRGXNGPPMF-UHFFFAOYSA-N

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Aplicação

Sulfanitran is used to stimulate MRP2. It is used to stimulate the MRP2-mediated transport of lipophilic amphipathic drugs. It is used to study the efflux of chemotherapeutics in tumor cell lines.

Ações bioquímicas/fisiológicas

Sulfanitran stimulates the ATP binding cassette family transporter multidrug resistance protein 2 (MRP2). Sulfanitran increases the affinity of MRP2 for estradiol-17-β-D-glucuronide. It stimulates the vectorial transport of saquinavir, a MRP2 substrate, across polarized MDCKII monolayers.

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Jurjen S Lagas et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(1), 129-136 (2008-10-11)
Diclofenac is an important analgesic and anti-inflammatory drug, widely used for treatment of postoperative pain, rheumatoid arthritis, and chronic pain associated with cancer. Consequently, diclofenac is often used in combination regimens and undesirable drug-drug interactions may occur. Because many drug-drug
Noam Zelcer et al.
The Journal of biological chemistry, 278(26), 23538-23544 (2003-04-19)
Multidrug resistance protein 2 (MRP2) belongs to the ATP binding cassette family of transporters. Its substrates include organic anions and anticancer drugs. We have used transport assays with vesicles derived from Sf9 insect cells overproducing MRP2 to study the interactions
Darko Ursic et al.
International journal of pharmaceutics, 381(2), 199-204 (2009-09-29)
Intestinal efflux transporters can significantly reduce the absorption of the drug after peroral application. In this work we studied secretion of glutathione conjugates triggered by glucose at the luminal side of the intestine. Glucose stimulated secretion of DNPSG, NEMSG and
Hehui Zheng et al.
Se pu = Chinese journal of chromatography, 25(2), 238-240 (2007-06-22)
A method for the determination of 12 sulfonamides (SAs) (sulfanilamide, sulfamonomethoxine, sulfacetamide, sulfamethoxazole, sulfadiazine, sulfisoxazole, sulfathiazole, sulfadi-methoxine, sulfamerazine, sulfaquinoxaline, sulfamethazine, sulfanitran) in cosmetics was developed by ultra performance liquid chromatography with photodiode array detector (UPLC-PDA). The chromatographic column used was
Marilyn J Schneider et al.
Analytical and bioanalytical chemistry, 407(15), 4423-4435 (2014-12-30)
Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical method to monitor up to 131

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