RAB1127
Mouse PAI-1 ELISA Kit
for cell culture supernatants, plasma, and serum samples
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
1 KIT
R$ 3.893,00
R$ 3.893,00
Previsão de entrega em11 de abril de 2025
Selecione um tamanho
Alterar visualização
1 KIT
R$ 3.893,00
About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
R$ 3.893,00
Previsão de entrega em11 de abril de 2025
reatividade de espécies
mouse, human
técnica(s)
ELISA: suitable
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/ml
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Descrição geral
The PAI-1 (plasminogen activator inhibitor) gene is localized to human chromosome 7q22.1.[1] Active form of PAI-1 is expressed in the blood and tissues. Platelets harbor both the active and latent forms of PAI-1.[2]
This ELISA antibody pair detects mouse and human PAI-1.
Aplicação
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Ações bioquímicas/fisiológicas
PAI-1 (plasminogen activator inhibitor) produced by platelets takes part in stabilizing blood clotting mechanism. PAI-1 prevents plasminogen activation during fibrinolysis. This might lead to the risk of cardiovascular disease. Elevated levels of PAI-1 has been observed in type 2 diabetes mellitus and serves the reason for reduced insulin sensitivity.[3] PAI-1 stimulates the process of cellular senescence. PAI-1 regulation occurs through p53 dependent TGF-β (transforming growth factor-β) signalling.[4] Studies also also predict that stress and depression might influence PAI-1 expression.[5]
Outras notas
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Met. Corr. 1
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
CpG methylation of the PAI-1 gene 5?-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines.
Gao S, et al.
Thrombosis and Haemostasis, 93(03), 651-660 (2005)
Hyperglycaemia-induced reciprocal changes in miR-30c and PAI-1 expression in platelets.
Luo M, et al.
Scientific Reports, 6, 36687-36687 (2016)
Plasminogen activator inhibitor-1 in depression: results from animal and clinical studies.
Jiang H, et al.
Scientific Reports, 6, 30464-30464 (2016)
Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 366-366 (2006)
TGF-? induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.
Kawarada Y, et al.
Scientific Reports, 6, 35483-35483 (2016)
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
