R125
Anti-RANTES antibody produced in goat
affinity isolated antibody, lyophilized powder
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
100 μG
R$ 4.118,00
Selecione um tamanho
Alterar visualização
100 μG
R$ 4.118,00
About This Item
Produtos recomendados
fonte biológica
goat
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
lyophilized powder
reatividade de espécies
human
técnica(s)
immunohistochemistry (frozen sections): suitable
neutralization: suitable
western blot: suitable
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CCL5(6352)
Descrição geral
RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The main function of RANTES is mediated by CCR5, CCR1, CCR3 and other receptors. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways. Polymorphisms in the gene encoding RANTES are implicated in artherosclerosis, multiple sclerosis, HIV infection, diabetes, inflammatory diseases of the lung, renal disease and systemic lupus erythematosus. In addition, RANTES is a potential prognostic factor to track the progression of stage II breast cancer
Anti-RANTES antibody specifically recognizes human RANTES. The antibody shows ~40% cross-reactivity with mouse RANTES and canine RANTES, ~20% cross-reactivity with cotton rat RANTES, and ~1% cross-reactivity with feline RANTES.
Anti-RANTES antibody specifically recognizes human RANTES. The antibody shows ~40% cross-reactivity with mouse RANTES and canine RANTES, ~20% cross-reactivity with cotton rat RANTES, and ~1% cross-reactivity with feline RANTES.
Especificidade
Based on ELISA, the antibody shows ~40% cross-reactivity with recombinant mouse RANTES, ~20% cross-reactivity with recombinant cotton rat RANTES, and ~1% cross-reactivity with recombinant feline RANTES.
Imunogênio
recombinant human RANTES expressed in E. coli.
Aplicação
Anti-RANTES antibody may be used for immunoblotting at a working concentration of 0.1 μg/ml. For immunohistochemistry and immunofluorescence, a working concentration of 5-15 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 0.1-0.4 μg/ml).
forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Não está encontrando o produto certo?
Experimente o nosso Ferramenta de seleção de produtos.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
F Villalta et al.
Infection and immunity, 66(10), 4690-4695 (1998-09-24)
This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta
Alan M Krensky et al.
Nature clinical practice. Nephrology, 3(3), 164-170 (2007-02-27)
Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues. Regulating expression of chemokines might, therefore, alleviate inflammation in autoimmune diseases and transplant rejection, or augment immune responses in cancer and immunodeficiency. RANTES (regulated upon
Caitlin M Guenther et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(3), 611-622 (2019-02-18)
Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of its non-pathogenicity, simple structure and genome, and low immunogenicity compared to other viruses. However, its adoption as a safe and effective delivery vector for certain diseases relies
Neora Yaal-Hahoshen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(15), 4474-4480 (2006-08-11)
The aim of this study was to determine the prognostic value of the chemokine CCL5, considered as a promalignancy factor in breast cancer, in predicting breast cancer progression and to evaluate its ability to strengthen the prognostic significance of other
V Appay et al.
Trends in immunology, 22(2), 83-87 (2001-04-05)
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
