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Merck
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PZ0196

Sigma-Aldrich

Tenidap

≥97% (HPLC)

Sinônimo(s):

(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide, CP 66248

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About This Item

Fórmula empírica (Notação de Hill):
C14H9ClN2O3S
Número CAS:
120210-48-2
Peso molecular:
320.75
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥97% (HPLC)

forma

powder

cor

faintly yellow to dark yellow

solubilidade

DMSO: 1 mg/mL, clear (warmed)

temperatura de armazenamento

2-8°C

InChI

1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)

chave InChI

IZSFDUMVCVVWKW-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC50 value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC50 values are 1.2 and > 30 μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC50 = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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M G Attur et al.
Osteoarthritis and cartilage, 6(4), 269-277 (1999-01-07)
To examine the effects of non-steroidal anti-inflammatory drugs (NSAIDS) on nitric oxide (NO) and prostaglandin E2 (PGE2) production in chondrocytes from three different species. We have estimated NO production by Griess method, and PGE2 by RIA from the supernatants of
Hiroko Matsumoto et al.
The Journal of pharmacology and experimental therapeutics, 300(2), 668-672 (2002-01-24)
The effect of tenidap [(+/-)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide], a new anti-inflammatory agent, was investigated on DNA synthesis by means of [(3)H]thymidine incorporation, collagen synthesis by means of [(3)H]proline incorporation, cell proliferation, and intracellular pH in nicardipine-reactive human gingival fibroblasts. Tenidap significantly inhibited [(3)H]thymidine
Samuel Parry et al.
The Journal of general virology, 87(Pt 8), 2269-2278 (2006-07-19)
The human placenta is relatively resistant to Human immunodeficiency virus 1 (HIV-1), but obstetric complications associated with inflammatory processes, including chorioamnionitis and spontaneous preterm delivery, are associated with increased rates of vertical transmission. It was hypothesized that the pro-inflammatory mediator
X Ayral et al.
Osteoarthritis and cartilage, 11(3), 198-207 (2003-03-08)
To test the hypothesis that tenidap has a structure-modifying effect in human knee osteoarthritis. multicenter, prospective, randomized, double blind, 1 year duration. primary painful knee osteoarthritis (ACR criteria) of the medial tibiofemoral compartment, medial joint space width > or =2mm
J C Fernandes et al.
The Journal of rheumatology, 25(5), 951-958 (1998-05-23)
To examine the effect of tenidap on the expression of collagenase- and interleukin 1beta (IL-1beta) genes in experimental canine osteoarthritis (OA). The anterior cruciate ligaments of the right stifle joints of experimental dogs were sectioned by a stab wound incision
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