P6188

Prostaglandin I₂ sodium salt

≥96% (HPLC), synthetic, powder

• Sinônimo(s): (5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI₂-Na, Prostacyclin sodium salt
• Fórmula empírica (Notação de Hill): C₂₀H₃₁NaO₅
• Número CAS: 61849-14-7
• Peso molecular: 374.45
• Beilstein: 6472195
• Número CE: 263-273-7
• Código UNSPSC: 12352401
• eCl@ss: 42020658
• ID de substância PubChem: 24898653
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic
• Ensaio: ≥96% (HPLC)
• Formulário: powder
• cor: white to off-white
• solubilidade: H₂O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F_1α in aqueous solution.); ethanol: 50 mg/mL
• grupo funcional: carboxylic acid; hydroxyl
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]
• InChI: 1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1
• chave InChI: OURCVRVJQMLUNA-QFDVFERUSA-M

Descrição

Aplicação

Prostaglandin I2 sodium salt has been used:

• in the preparation of stock solution for platelet washing procedure[1]
• as supplement in platelet-rich-plasma, for platelet preparation[2]
• to prevent platelet activation[3]

Ações bioquímicas/fisiológicas

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A₂ and stimulating platelet adenylyl cyclase.[4] Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves