P6124

5-(4-Phenoxybutoxy)psoralen

≥98% (HPLC), solid

• Sinônimo(s): PAP-1
• Fórmula empírica (Notação de Hill): C₂₁H₁₈O₅
• Número CAS: 870653-45-5
• Peso molecular: 350.36
• Número MDL: MFCD11114059
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724583
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: white
• solubilidade: DMSO: 9 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1Oc2cc3occc3c(OCCCCOc4ccccc4)c2C=C1
• InChI: 1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
• chave InChI: KINMYBBFQRSVLL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

5-(4-Phenoxybutoxy)psoralen (PAP-1) is derived from 5-methoxypsoralen, a natural compound. PAP-1 show higher selectivity for Kv1.3 (voltage-gated potassium channels) than other Kv1 family members. Kv1.3 is predominant on cell membranes of activated effector memory T-cells. Inhibition of Kv1.3 results in membrane depolarization. In rat models, PAP-1 is known to delay the onset of diabetes.[1] It might be used in the treatment of psoriasis and effector memory T cells mediated autoimmune diseases.[2] Oral, intraperitoneal and topical administration of PAP-1 prevents allergic contact dermatitis induced by oxazolone.[3]

Selective inhibitor of K_v1.3, voltage-gated K⁺ channel.

Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC₅₀=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.

Características e benefícios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H334
• Declarações de precaução: P261 - P284 - P501
• Classificações de perigo: Resp. Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves