P4235

Anti-p53 antibody produced in sheep

fractionated antiserum, buffered aqueous solution

• Número MDL: MFCD00164709
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: sheep
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: fractionated antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen 53 kDa
• reatividade de espécies: rat, mouse, human
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunoprecipitation (IP): suitable; western blot: 1-10 μg/mL
• nº de adesão UniProt: P04637
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... TP53(7157) ; mouse ... Trp53(22059) ; rat ... Tp53(24842)

Descrição

Descrição geral

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Imunogênio

GST fusion protein of human p53 corresponding to amino acids 1-393.

Aplicação

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

Ações bioquímicas/fisiológicas

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

forma física

Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable