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P2871

Sigma-Aldrich

Anti-Cytokeratin pan antibody, Mouse monoclonal

clone C-11, purified from hybridoma cell culture

Sinônimo(s):

Anti-CK-4, Anti-CK4, Anti-CYK4, Anti-K4, Anti-WSN1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified from hybridoma cell culture

tipo de produto de anticorpo

primary antibodies

clone

C-11, monoclonal

forma

buffered aqueous solution

técnica(s)

immunocytochemistry: 15-30 μg/mL using methanol/acetone-fixed PTK-2 cells or A549 - human lung carcinoma cells
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 15-30 μg/mL using human skin
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Categorias relacionadas

Descrição geral

Monoclonal Anti-Cytokeratin, pan (mouse IgG1 isotype) is derived from the C-11 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a keratin-enriched preparation from cultured human epidermoid carcinoma cell line A431. Cytokeratin is a member of the intermediate filaments family.

Aplicação

Monoclonal Anti-Cytokeratin pan antibody has been used in immunoblotting, dot blot, immunohistochemistry, immunocytochemistry, immunofluorescence, immunostaining, detecting micro-metastases in lymph nodes, bone marrow, and other tissues and for determining the origin of poorly differentiated tumors.

Ações bioquímicas/fisiológicas

Cytokeratin plays a major role in observing carcinomas.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificados de análise (COA)

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Gloria Valdés et al.
Reproductive sciences (Thousand Oaks, Calif.), 27(8), 1648-1655 (2020-05-21)
The pleiotropic kininogen-kallikrein-kinin system is upregulated in pregnancy and localizes in the uteroplacental unit. To identify the systemic and local participation of the bradykinin type 2 receptor (B2R), this was antagonized by Bradyzide (BDZ) during 2 periods: from days 20
Spatio-temporal expression of MMP-2, MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig (Cavia porcellus)
Corthorn J, et al.
Reproductive Biology and Endocrinology, 5(1), 27-27 (2007)
Utero-placental expression of angiotensin-(1-7) and ACE2 in the pregnant guinea-pig
Valdes G, et al.
Reproductive Biology and Endocrinology, 11(1), 5-5 (2013)
Aminah Ali Abid Al-Juboori et al.
Proteomics, 19(21-22), e1800448-e1800448 (2019-03-14)
Epithelial and stromal communications are essential for normal uterine functions and their dysregulation contributes to the pathogenesis of many diseases including infertility, endometriosis, and cancer. Although many studies have highlighted the advantages of culturing cells in 3D compared to the
Co-culture with endometrial stromal cells enhances the differentiation of human embryonic stem cells into endometrium-like cells
Yu W, et al.
Experimental and Therapeutic Medicine, 10(1), 43-50 (2015)

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