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P102

Sigma-Aldrich

R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride

solid

Sinônimo(s):

R(+)-3-PPP hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C14H21NO · HCl
Número CAS:
89874-80-6
Peso molecular:
255.78
Número MDL:
MFCD00055194
Código UNSPSC:
12352200
ID de substância PubChem:
24277924
NACRES:
NA.77

forma

solid

cor

white

solubilidade

H2O: 150 mg/mL
ethanol: slightly soluble

cadeia de caracteres SMILES

Cl.CCCN1CCC[C@@H](C1)c2cccc(O)c2

InChI

1S/C14H21NO.ClH/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12;/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3;1H/t13-;/m0./s1

chave InChI

NRHUDETYKUBQJT-ZOWNYOTGSA-N

Informações sobre genes

human ... DRD2(1813)

Ações bioquímicas/fisiológicas

D2 dopamine receptor agonist. Also functions as σ1 receptor antagonist with essentially no affinity for the phencylidine site on the NMDA receptor.

Nota de preparo

Solutions should be freshly prepared.

Informações legais

Sold with the permission of Astra Pharmaceutical Co.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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M C Coldwell et al.
British journal of pharmacology, 127(5), 1135-1144 (1999-08-24)
This study characterized pharmacologically the functional responses to agonists at human dopamine D2(long) (hD2), D3 (hD3) and D4.4 (hD4) receptors separately expressed in cloned cells using the cytosensor microphysiometer. Dopaminergic receptor agonists caused increases in extracellular acidification rate in adherent
R Bergeron et al.
Psychopharmacology, 129(3), 215-224 (1997-02-01)
Several high affinity sigma (sigma) ligands, such as DTG, JO-1784, (+)-pentazocine, BD-737 and L-687,384, administered at low doses act as agonists by potentiating N-methyl-D-aspartate (NMDA)-induced activation of pyramidal neurons in the CA3 region of the rat dorsal hippocampus. This potentiation
S Tokuyama et al.
Neuroscience letters, 233(2-3), 141-144 (1997-11-14)
We studied effects of various sigma ligands on GTPase activity in mouse prefrontal membranes. Some representative sigma agonists, such as (+)-pentazocine, SA4503 and (+)-3-PPP, stimulated the GTPase activity in a concentration-dependent manner in ranges of 10 nM to 10 microM.
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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