N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

• Sinônimo(s): Naltrexone HCl
• Fórmula empírica (Notação de Hill): C₂₀H₂₃NO₄ · HCl
• Número CAS: 16676-29-2
• Peso molecular: 377.86
• Beilstein: 3580333
• Número CE: 240-723-0
• Número MDL: MFCD00069324
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278051
• NACRES: NA.77

Propriedades

• product name: Naltrexone hydrochloride,
• forma: powder
• originador: Novartis
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6
• InChI: 1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
• chave InChI: RHBRMCOKKKZVRY-ITLPAZOVSA-N
• Informações sobre genes: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Descrição

Aplicação

Naltrexone hydrochloride has been used:

• as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
• to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
• in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Ações bioquímicas/fisiológicas

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves