MAK422

ACE1 Inhibitor Screening Kit (Colorimetric)

sufficient for 100 colorimetric tests

• Código UNSPSC: 12161503

Propriedades

• método de detecção: colorimetric
• doença(s) relevante(s): endocrinological disorders, diabetes; cardiovascular diseases; neurological disorders
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors.

Características e benefícios

ACE1 Inhibitor Screening Kit:

• Compatible with high-throughput handling systems.

Adequação

The kit is suitable for the screening/characterizing of ACE1 inhibitors.

Princípio

The ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in A₃₄₅ nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the A₃₄₅ nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360F
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects