M9948

Mirin

≥98% (HPLC), powder

• Sinônimo(s): 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
• Fórmula empírica (Notação de Hill): C₁₀H₈N₂O₂S
• Número CAS: 299953-00-7
• Peso molecular: 220.25
• Número MDL: MFCD05885480
• Código UNSPSC: 12352200
• ID de substância PubChem: 329818100
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: red to orange
• solubilidade: DMSO: >10 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
• InChI: 1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
• chave InChI: YBHQCJILTOVLHD-YVMONPNESA-N
• Informações sobre genes: human ... MRE11A(4361)

Descrição

Aplicação

Mirin has been used:

• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Ações bioquímicas/fisiológicas

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Mirin is an inhibitor of the Mre11–Rad50–Nbs1 complex.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable