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M9292

Sigma-Aldrich

Memantine hydrochloride

≥98% (GC), powder, NMDA glutamate receptor antagonist

Sinônimo(s):

3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C12H21N · HCl
Número CAS:
41100-52-1
Peso molecular:
215.76
Número CE:
255-219-6
Número MDL:
MFCD00214336
Código UNSPSC:
12352200
ID de substância PubChem:
24277990
NACRES:
NA.77

product name

Memantine hydrochloride, ≥98% (GC)

Ensaio

≥98% (GC)

forma

powder

originador

Forest Labs

cadeia de caracteres SMILES

Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2

InChI

1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;

chave InChI

LDDHMLJTFXJGPI-VXMZOEJHSA-N

Informações sobre genes

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Aplicação

Memantine hydrochloride has been used:
  • as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity
  • to intraperitoneally inject experimental animal to study its effect on traumatic injury
  • as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration

Ações bioquímicas/fisiológicas

Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.
Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.

Características e benefícios

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Anton N Shuvaev et al.
Brain sciences, 12(4) (2022-04-22)
Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the inhibition of extrasynaptic NMDA receptors in patients and mouse models. Potentially, it could prevent neurodegeneration in other
Dementia of Alzheimer?s disease and other neurodegenerative disorders-memantine, a new hope
Sonkusare SK, et al.
Pharmacological Research, 51(1), 1-17 (2005)
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Kelestemur T, et al.
Neuroscience Letters, 612(1), 92-97 (2016)
Anton N Shuvaev et al.
International journal of molecular sciences, 22(15) (2021-08-08)
Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common pathogenetic mechanism, such as insufficient glutamate clearance. This function fails in reactive glia, leading to excitotoxicity and
C G Parsons et al.
Neuropharmacology, 32(12), 1337-1350 (1993-12-01)
Memantine (1-amino-3,5-dimethyladamantan) was tested as an antagonist of N-methyl-D-aspartate (NMDA) receptors on cultured superior collicular and hippocampal neurones using the patch clamp technique and its actions were compared to those of Mg2+ ions, ketamine, dextrorphan, dextromethorphan, phencyclidine and dizocilpine (MK-801).
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