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L137

Sigma-Aldrich

L-733,060 hydrochloride

solid, ≥98% (HPLC)

Sinônimo(s):

(2S,3S)-3-[(3,5-bis(Trifluoromethyl)phenyl)methoxy]-2-phenylpiperidine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C20H19F6NO · HCl
Número CAS:
148687-76-7
Peso molecular:
439.82
Número MDL:
MFCD06798982
Código UNSPSC:
12352202
ID de substância PubChem:
24278530

Ensaio

≥98% (HPLC)

forma

solid

cor

white

solubilidade

DMSO: >10 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl[H].FC(F)(F)c1cc(CO[C@@H]2CCCN[C@@H]2c3ccccc3)cc(c1)C(F)(F)F

Informações sobre genes

human ... TACR1(6869)

Ações bioquímicas/fisiológicas

Non-peptide NK1 tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse. Micromolar concentrations of L-733,060 inhibit the growth of human gastric and colon adenocarcinomas.in a dose-dependent manner, eventually leading to apoptosis in both cell lines.

Informações legais

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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P Kiatpapan et al.
Journal of bioscience and bioengineering, 92(5), 459-465 (2005-10-20)
To develop systems for the expression of heterologous genes in probiotic strains of Lactobacillus and Propionibacterium, we used Lactobacillus plantarum and Propionibacterium freudenreichii and a modified gene encoding cholesterol oxidase (choA) from Streptomyces sp. to generate working models. The acetyl
Jitka Myskova et al.
Journal of medical entomology, 45(1), 133-138 (2008-02-21)
Quantification of Leishmania parasites in the sand fly digestive tract is important for evaluation of vector competence. We compared quantitative polymerase chain reaction (Q-PCR) with two "traditional" methods, estimation in situ and direct counting with the aid of a hemocytometer
Y Kaneko et al.
Journal of bioscience and bioengineering, 89(1), 62-67 (2005-10-20)
Lactobacillus plantarum NC13, a strain derived from the L. plantarum strain L137 isolated from a traditional fermented food produced in the Philippines, contains 9 of the 15 plasmids in the parental strain. To construct a shuttle vector between L. plantarum
Jong-Hyun Kim et al.
Journal of bioscience and bioengineering, 107(2), 124-129 (2009-02-17)
A gene (apuA) encoding amylopullulanase from a starch-hydrolyzing lactic acid bacterium, Lactobacillus plantarum L137, which had been isolated from traditional fermented food made from fish and rice in the Philippines, was found to contain two unique amino acid repeating units
Marisa Rosso et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 29(4), 245-254 (2008-09-11)
It has been demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonist L-733,060 induces cell proliferation and inhibition, respectively, in several human cancer cell lines. At present, it is unknown whether such actions are exerted on human gastric and
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