Anti-Transferrin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also used for indirect ELISA.
Ações bioquímicas/fisiológicas
Transferrin is a glycoprotein that binds to and transports Fe3+ ions from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. It may also stimulate cell proliferation by supplying iron during DNA synthesis. Abnormal synthesis of transferrin may lead to accumulation of iron and microcytic hypochromic anemia.
forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Exoneração de responsabilidade
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Infection and immunity, 44(2), 320-325 (1984-05-01)
Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does
A mechanism is proposed by which apotransferrin is secreted from mucosal cells, loaded with iron in the intestinal lumen, and then the intact complex is taken into the cell. Within the cell, iron is released and transferred to the blood
The role of transferrin in the mechanism of cellular iron uptake.
Transferrin is essential for cell proliferation and it was suggested that it may trigger a proliferative response following its interaction with receptors, serving as a growth factor. However, since the only clearly defined function of transferrin is iron transport, it
Molecular characterization of a third case of human atransferrinemia.
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