G6423

Gemcitabine hydrochloride

≥98% (HPLC), powder, antitumor agent

• Sinônimo(s): 2′-Deoxy-2′,2′-difluorocytidine; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
• Fórmula empírica (Notação de Hill): C₉H₁₁F₂N₃O₄ · HCl
• Número CAS: 122111-03-9
• Peso molecular: 299.66
• Número MDL: MFCD01735988
• Código UNSPSC: 12352200
• ID de substância PubChem: 329799951
• NACRES: NA.77

Propriedades

• Nome do produto: Gemcitabine hydrochloride, ≥98% (HPLC)
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated; protect from light
• solubilidade: H₂O: ≥10 mg/mL
• originador: Eli Lilly
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
• InChI: 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
• chave InChI: OKKDEIYWILRZIA-OSZBKLCCSA-N
• Informações sobre genes: human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558) , RRM1(6240) , RRM2(6241) , RRM2B(50484)

Descrição

Descrição geral

Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.[1]

Aplicação

Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell line[2]It has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)[3]It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.[4]

Ações bioquímicas/fisiológicas

Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H360
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable