G6416

GW5074

powder

• Sinônimo(s): 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
• Fórmula empírica (Notação de Hill): C₁₅H₈Br₂INO₂
• Número CAS: 220904-83-6
• Peso molecular: 520.94
• Número MDL: MFCD03453076
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278455
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• Formulário: powder
• condição de armazenamento: protect from light
• cor: yellow to orange-brown
• solubilidade: DMSO: 5 mg/mL, clear
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Oc1c(Br)cc(cc1Br)\C=C2/C(=O)Nc3ccc(I)cc23
• InChI: 1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
• chave InChI: LMXYVLFTZRPNRV-KMKOMSMNSA-N
• Informações sobre genes: human ... RAF1(5894)

Descrição

Aplicação

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts,[1] HT-29 colorectal adenocarcinoma cell line [2] and neutrophils.[3]

Ações bioquímicas/fisiológicas

GW5074 is a cRaf1 kinase inhibitor,[4] which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway.[5] It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.[6]

Outras notas

light sensitive

Informações legais

Sold for research purposes under agreement from Glaxo­Smith­Kline

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)