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G1049

Sigma-Aldrich

Poly-L-γ-glutamic acid sodium salt

suitable for drug transporter assays, Mol wt ≥750,000

Sinônimo(s):

γ-PGA

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100 MG
R$ 2.151,00

R$ 2.151,00

Disponível para enviar em07 de abril de 2025Detalhes

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100 MG
R$ 2.151,00

About This Item

Número CAS:
208106-41-6
Número MDL:
MFCD00081868
Código UNSPSC:
12352209
NACRES:
NA.26

R$ 2.151,00

Disponível para enviar em07 de abril de 2025Detalhes

Solicite uma grande encomenda

Nome do produto

Poly-L-γ-glutamic acid sodium salt,

Formulário

powder

peso molecular

≥750,000

técnica(s)

drug transporter assay: suitable

cor

white to off-white

aplicação(ões)

cell analysis

temperatura de armazenamento

−20°C

Categorias relacionadas

Aplicação

High molecular weight poly-γ-glutamic acid (γPGA) was found to increase levels of NK cell-mediated cytotoxicity and INF-γ secretion in C57BL/6 mice.[1] Biodegradable γ-PGA nanoparticles have been evaluated for use as antigen delivery carriers[2] and delivery of influenza virus hemagglutin (HA) vaccine.[3] Additional life science applications for γ-PGA include uses in biodegradable fibers and nanofiber sheets, hydrogels, and cryoprotectants.[4][5][6]

Outras notas

High molecular weight poly-γ-glutamic acid is a polymer of glutamic acid connected by amide linkages between α-amino and γ-carboxylic acid groups. γ-PGA is produced by fermentation in Bacillus species. The subunits are predominantly L-isomer.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
MKCV0152
MKCQ9820
MKCR5164
MKCN8813
MKCL8712

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Preparation and evaluation of poly(γ-glutamic acid)-based anti-adhesion membranes.
Kim, Y.-A., et al.
Key Engineering Materials, 342, 225-225 (2007)
Shigefumi Okamoto et al.
Vaccine, 27(42), 5896-5905 (2009-08-04)
Adding poly(gamma-glutamic acid) nano-particles (gamma-PGA-NPs), a safe, natural material, to subcutaneous immunization with influenza virus hemagglutinin (HA) vaccine increases the protective immune responses against influenza virus in mice. Here, we examined whether intranasal administration of the HA vaccine with gamma-PGA-NPs
The utility of poly(γ-glutamic acid) nanoparticles as antigen delivery carriers in dendritic cell-based cancer immunotherapy.
Matsuo, K., et al.
Biological & Pharmaceutical Bulletin, 33, 2007-2007 (2010)
Ilaria Massaiu et al.
Microbial cell factories, 18(1), 3-3 (2019-01-11)
Genome-scale metabolic models (GEMs) allow predicting metabolic phenotypes from limited data on uptake and secretion fluxes by defining the space of all the feasible solutions and excluding physio-chemically and biologically unfeasible behaviors. The integration of additional biological information in genome-scale models
I L Shih et al.
Bioresource technology, 79(3), 207-225 (2001-08-14)
This review article deals with the chemistry and biosynthesis of poly-(gamma-glutamic acid) (gamma-PGA) produced by various strains of Bacillus. Potential applications of gamma-PGA as thickener, cryoprotectant, humectant, drug carrier, biological adhesive, flocculant, or heavy metal absorbent, etc. with biodegradability in
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Is G1049 product free of endotoxin? 

    1 answer

    1. Unfortunately, this product is not tested to determine endotoxin.

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