F3679
Anti-Frizzled-7 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-FZD7
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About This Item
conjugado:
unconjugated
application:
IHC (p)
clone:
polyclonal
reatividade de espécies:
human
citations:
5
técnica(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human kidney
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
disponibilidade
not available in Japan
técnica(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4 μg/mL using human kidney
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... FZD7(8324)
mouse ... Fzd7(14369)
Descrição geral
Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues such as skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex. In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. FZD7 is expressed throughout normal gastrointestinal tract, from esophagus to rectum. It is highly expressed in the gastric cancer cell line MKN7 and relatively lowers in esophageal cancer cell lines.
Imunogênio
synthetic peptide corresponding to the N-terminal extracellular domain of human frizzled-7, conjugated to KLH. The immunizing peptide has 100% homology with the mouse gene.
Aplicação
Anti-Frizzled-7 antibody is suitable for immunostaining of liver tissues to localise FZD7 in T and pT tissues. It is also suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL using human kidney.
Ações bioquímicas/fisiológicas
FZD7 shows 98.8% nucleotide identity with FzE3 and encodes for WNT receptors with nine amino-acid substitutions. In human primary gastric cancer, high level of FZD7 has been found. Mechanistically, over-expression of Frizzled-7 accelerates the WNT-β-catenin-TCF pathway. Through the activation of the WNT-β-catenin-TCF pathway, FZD7, might play key roles in carcinogenesis.
forma física
Solution in phosphate buffered saline containing 0.01% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
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A Bengochea et al.
British journal of cancer, 99(1), 143-150 (2008-06-26)
Dysregulation of growth factors and their receptors is central to human hepatocellular carcinoma (HCC). We previously demonstrated that the Frizzled-7 membrane receptor mediating the Wnt signalling can activate the beta-catenin pathway and promotes malignancy in human hepatitis B virus-related HCCs.
H Kirikoshi et al.
International journal of oncology, 19(1), 111-115 (2001-06-16)
Human Frizzled-7 (FZD7) and human FzE3, showing 98.8% nucleotide identity, encode almost identical WNT receptors with nine amino-acid substitutions. FzE3 is claimed to be expressed specifically in esophageal cancer. We determined the structure of the FZD7 gene and the FZD7
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
H Kirikoshi et al.
International journal of oncology, 19(4), 767-771 (2001-09-20)
Frizzled (FZD) genes encode seven-transmembrane type WNT receptors, which are implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, and FZD10. Here, we investigated expression profiles of all members of
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
Artigos
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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