E1645
Anti-Endothelin antibody produced in rabbit
whole antiserum
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About This Item
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
whole antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
contém
15 mM sodium azide
reatividade de espécies
human, rat, pig
técnica(s)
indirect ELISA: 1:30,000
radioimmunoassay: 1:10,000 using 125I-endothelin-1, human
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... EDN1(1906)
rat ... Edn1(24323)
Descrição geral
Endothelin consists of a family of potent vasoconstrictor peptides, which include four structurally related isoforms, ET-1, ET-2, ET-3 and vasointestinal contractor (VIC, β-ET).
Especificidade
Reacts with endothelin-1 (ET-1), (human, porcine), endothelin-2 (ET-2), (human), and endothelin-3 (ET-3), (human, rat). Cross-reactivity is seen with sarafotoxin S6c, but not with big-endothelin 38 (human), big-endothelin 39 (rat) or atrial natriuretic peptide (human). There is minimal cross-reaction with angiotensin I (human).
Imunogênio
synthetic human endothelin-1 conjugated to KLH
Aplicação
Anti-Endothelin antibody produced in rabbit is suitable for immunodetection of endothelins (ET-1, ET-2, and ET-3) in various immunoassays including RIA (titer of 1:30,000) and ELISA (titer of 1:10,000). Antibodies that react specifically with endothelins (ET-1, ET-2, and ET-3) may be used to detect endothelins in tissue extracts and biological fluids as well as study differential tissue expression, and intracellular localization of the endothelin isoforms in the periphery and central nervous system.
Ações bioquímicas/fisiológicas
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. ETs can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. The biological actions of ETs are mediated by activation of phospholipase C through specific G protein-coupled receptors.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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T Sakurai et al.
Trends in pharmacological sciences, 13(3), 103-108 (1992-03-01)
Following the first report on the identification of endothelin (ET), an increasing body of work has accumulated on this endothelium-derived 21-amino acid vasoconstrictor peptide. Subsequently, the existence of three distinct isoforms of ET, designated ET-1, ET-2 and ET-3, was predicted
Endothelin: localization, synthesis, activity, and receptor types in human penile corpus cavernosum.
I Saenz de Tejada et al.
The American journal of physiology, 261(4 Pt 2), H1078-H1085 (1991-10-01)
The localization, synthesis, and activity of endothelin and the receptor types mediating its effects in penile corpus cavernosum were investigated in whole tissue and in cultured cells derived from this tissue. With immunocytochemistry, utilizing an antiendothelin 1 (ET-1) monoclonal antibody
A Inoue et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(8), 2863-2867 (1989-04-01)
Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endothelin sequence. Genomic Southern blot analysis with the same oligonucleotide probe showed
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