E1518
Echistatin from Echis carinatus
lyophilized powder, γ-irradiated, BioXtra
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About This Item
Produtos recomendados
fonte biológica
Echis carinatus
Nível de qualidade
esterilidade
γ-irradiated
linha de produto
BioXtra
Ensaio
>95% (SDS-PAGE)
forma
lyophilized powder
peso molecular
5.2-5.4 kDa
embalagem
pkg of 50 μg
técnica(s)
cell culture | mammalian: suitable
solubilidade
water: soluble 0.1 mg/mL, clear, colorless
Condições de expedição
ambient
temperatura de armazenamento
−20°C
chave InChI
XLBBKEHLEPNMMF-SSUNCQRMSA-N
Descrição geral
Echistatin is a small peptide disintegrin that has no multiple epitopes. It is a single chain polypeptide with a molecular mass of 5400. Echistatin has eight cysteines and the sequence arginine glycine aspartic acid (RGD).
Aplicação
Echistatin from Echis carinatus has been used in diabetic rabbits grouping and treatment and murine iPSC (induced pluripotent stem cell) culture.
Ações bioquímicas/fisiológicas
Echistatin has the ability to prevent IRS-1 (insulin receptor substrate-1) phosphorylation induced by IGF-1 (insulin like growth factor-1). Echistatin α1, purified from the venom of the saw scaled viper, Echis carinatus has the capability to block platelet aggregation.
Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Fengbin Lin et al.
International journal of clinical and experimental pathology, 8(11), 14294-14304 (2016-01-30)
To investigate the effect of disintegrin echistatin on integrin linked kinase (ILK) and subsequent PI3-K/Akt and ERK1/2 signaling pathways in the posterior capsule opacification (PCO) model of diabetic rabbit. 56 rabbits were injected alloxan to model diabetic. Then they accepted
Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.
Lin F, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 14294-14294 (2015)
Animal Toxins: Facts and Protocols (2013)
Ozge Er et al.
Applied biochemistry and biotechnology, 187(4), 1539-1550 (2018-10-03)
Snake venoms are a natural biological source that has potential therapeutic value with various protein compounds. Disintegrins originally were discovered as a family of proteins from snake venoms composed of cysteine rich low molecular weight polypeptides. Disintegrins exhibit specific binding
Insulin-like Growth Factor Receptor Signalling (2003)
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