D3321
Dipeptidyl Peptidase VII human
recombinant, expressed in Sf9 cells
Sinônimo(s):
DPP7, Quiescent cell proline dipeptidase
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10 μG
R$ 5.036,00
R$ 5.036,00
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10 μG
R$ 5.036,00
About This Item
Número da licença da enzima:
3.4.14.-
Código UNSPSC:
12352204
NACRES:
NA.54
R$ 5.036,00
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Produtos recomendados
recombinante
expressed in Sf9 cells
Nível de qualidade
Formulário
solution
atividade específica
≥1,500 units/μg protein
≥1500 units/μg protein
peso molecular
89.1 kDa
doença(s) relevante(s)
diabetes; cardiovascular diseases
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Categorias relacionadas
Aplicação
Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes [1]. DPP7 is used to study the regulation of cell quiescence [2]. Like DPP4, DPP7 may be useful in diabetes and vascular disease research [3].
Ações bioquímicas/fisiológicas
DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53 [2]. DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.
propriedades físicas
Contains amino acids 29 to end with a C-terminal His tag, MW=89.1 kDa
Definição da unidade
One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C
forma física
Supplied as a solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Dam. 1 - Repr. 1B - Skin Corr. 1C
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 2
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Martin Kruse et al.
The Journal of general physiology, 140(2), 189-205 (2012-08-02)
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) regulates activities of numerous ion channels including inwardly rectifying potassium (K(ir)) channels, KCNQ, TRP, and voltage-gated calcium channels. Several studies suggest that voltage-gated potassium (K(V)) channels might be regulated by PI(4,5)P(2). Wide expression of K(V) channels in
Katrin Witzel et al.
Neuropharmacology, 63(8), 1389-1403 (2012-09-12)
We examined the effects of the sulfonylurea compound NS5806 on neuronal A-type channel function. Using whole-cell patch-clamp we studied the effects of NS5806 on the somatodendritic A-type current (I(SA)) in cultured hippocampal neurons and the currents mediated by Kv4.2 channels
Dipeptidyl peptidase 2 is an essential survival factor in the regulation of cell quiescence.
Mele DA, et al.
Cell Cycle, 15, 2425-2434 (2009)
Mahesh Kamate et al.
Neurology India, 60(3), 316-320 (2012-07-25)
Neuronal ceroid lipofuscinosis is a group of progressive neurodegenerative disorders characterized by accumulation of ceroid lipopigment in lysosomes in neurons and other cell types. This study is a retrospective review of charts of patients with a diagnosis of infantile and
Lin Zhu et al.
The Journal of general and applied microbiology, 58(3), 199-209 (2012-08-11)
Proteolytic degradation is one of the serious bottlenecks limiting the yields of heterologous protein production by Aspergillus oryzae. In this study, we selected a tripeptidyl peptidase gene AosedD (AO090166000084) as a candidate potentially degrading the heterologous protein, and performed localization
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