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C4403

Sigma-Aldrich

Calcium Ionophore A23187 mixed calcium magnesium salt

Approximate 1:15 molar ratio Ca:Mg.

Sinônimo(s):

Calcimycin, Calcium Ionophore mixed calcium magnesium salt

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About This Item

Fórmula empírica (Notação de Hill):
C29H37N3O6
Peso molecular:
523.62
Número MDL:
MFCD00213962
Código UNSPSC:
12352202
ID de substância PubChem:
24892691
NACRES:
NA.77

forma

solid

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Mg++].[Ca++].CNc1ccc2oc(CC3OC4(CCC3C)OC(C(C)CC4C)C(C)C(=O)c5ccc[nH]5)nc2c1C(O)=O

InChI

1S/C29H37N3O6.Ca.Mg/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;;/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);;/q;2*+2

chave InChI

HKVXGTQLKZNXPV-UHFFFAOYSA-N

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Aplicação

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not to quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Outras notas

Ca and Mg contents may vary; actual content given on label.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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In vertebrates, the iron exporter ferroportin releases Fe(2+) from cells into plasma, thereby maintaining iron homeostasis. The transport activity of ferroportin is suppressed by the peptide hormone hepcidin, which exhibits upregulated expression in chronic inflammation, causing iron-restrictive anaemia. However, due
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Molecular cell, 74(6), 1123-1137 (2019-05-06)
Abnormal processing of stressed replication forks by nucleases can cause fork collapse, genomic instability, and cell death. Despite its importance, it is poorly understood how the cell properly controls nucleases to prevent detrimental fork processing. Here, we report a signaling
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 583-598 (2015-01-16)
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