B3056
Bisindolylmaleimide II
≥97% (Mixture of 2 isomers)
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About This Item
Fórmula empírica (Notação de Hill):
C27H26N4O2
Número CAS:
Peso molecular:
438.52
Número MDL:
Código UNSPSC:
12352111
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
fonte biológica
synthetic (organic)
Nível de qualidade
Ensaio
≥97% (Mixture of 2 isomers)
Formulário
powder
solubilidade
DMSO: soluble
ethanol: soluble
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
CN1CCCC1CCn2cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c6ccccc26
InChI
1S/C27H26N4O2/c1-30-13-6-7-17(30)12-14-31-16-21(19-9-3-5-11-23(19)31)25-24(26(32)29-27(25)33)20-15-28-22-10-4-2-8-18(20)22/h2-5,8-11,15-17,28H,6-7,12-14H2,1H3,(H,29,32,33)
chave InChI
LBFDERUQORUFIN-UHFFFAOYSA-N
Aplicação
Bisindolylmaleimide II (BIS II) has been used:
- as a protein kinase C (PKC) inhibitor to study its effects on cardiomyocyte phenotypes[1]
- as a PKC inhibitor along with methanandamide (mAEA) to study its effects on murine gastric vagal afferent (GVA) mechanosensitivity[2]
- as a PKC/protein kinase A (PKA) inhibitor to study its effects on bone-marrow cells[3]
Ações bioquímicas/fisiológicas
Bisindolylmaleimide II (BIS II) acts as a dual protein kinase A/C (PKA/C) inhibitor.[3]
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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S E Wang et al.
Oncogene, 29(23), 3335-3348 (2010-04-13)
Activating mutations in the tyrosine kinase domain of HER2 (ErbB2) have been identified in human cancers. Compared with wild-type HER2, mutant HER2 shows constitutively activate kinase activity and increased oncogenicity. Cells transformed by mutant HER2 are resistant to epidermal growth
Ameneh Cheshmehkani et al.
Biochemical pharmacology, 146, 139-150 (2017-09-26)
Agonism of the G protein-coupled free-fatty acid receptor-4 (FFA4) has been shown to promote numerous anti-inflammatory effects in macrophages that arise due to interaction with β-arrestin partner proteins. Humans express functionally distinct short and long FFA4 splice variants, such that
Xiaojie Shi et al.
Brain research bulletin, 130, 138-145 (2017-01-25)
Carnosine is believed to be neuroprotective in cerebral ischemia. However, few reports concern its function on senescent astrocytes during cerebral ischemia. The aim of this study was to investigate the effects of carnosine on cell damage and glutamine synthetase (GS)
Petr Heneberg et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 49(1), 54-67 (2018-10-06)
CD16 was previously suggested to be a new marker of basophils that is subject to downregulation by FcεRI crosslinking. Certain compounds, including supraoptimal concentrations of the PKC inhibitors, bisindolylmaleimides, decouple the release of granules containing CD203c, CD63 and histamine, and
Binh Thanh Nguyen et al.
Electrophoresis, 37(23-24), 3146-3153 (2016-10-27)
An assay for protein kinase C delta (PKCδ) activity based on the quantification of a synthetic substrate using capillary electrophoresis with laser-induced fluorescence detection was developed. The peptides labeled with fluorescein isothiocyanate F-ERK (where ERK is extracellular signal-regulated kinase) and
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