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Documentos Principais

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B174

Sigma-Aldrich

BIBP 3226

Sinônimo(s):

N2-(Diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide

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About This Item

Fórmula empírica (Notação de Hill):
C27H31N5O3
Número CAS:
159013-54-4
Peso molecular:
473.57
Número MDL:
MFCD00938562
Código UNSPSC:
12352200
ID de substância PubChem:
24891607
NACRES:
NA.77

Ensaio

≥95%

solubilidade

H2O: 1 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c2ccccc2)C(=O)NCc3ccc(O)cc3

InChI

1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)/t23-/m1/s1

chave InChI

KUWBXRGRMQZCSS-HSZRJFAPSA-N

Ações bioquímicas/fisiológicas

Selective non-peptide neuropeptide Y1 (NPY1) receptor antagonist.

Características e benefícios

This compound is featured on the Neuropeptide Y Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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I R Tough et al.
European journal of pharmacology, 310(1), 55-60 (1996-08-22)
BIBP3226 (N2-(diphenylacetyl)-N-[4-hydroxyphenyl)methyl]-D-arginine amide) has been used to examine the presence of neuropeptide Y Y1 receptors in 3 gastrointestinal epithelial preparations, namely the rat jejunum and descending colon mucosae and a human colonic adenocarcinoma cell line. The selective Y1 receptor antagonist
Tiara Lacey et al.
Neuroscience letters, 690, 214-218 (2018-10-13)
Recent evidence indicates that Neuropeptide Y (NPY) may function as a potent anxiolytic as well as a resilience factor that can insulate the brain from the effects of stress. However, most of these studies have utilized physical stressors such as
P M Vanderheyden et al.
European journal of pharmacology, 331(2-3), 275-284 (1997-07-23)
[3H]Neuropeptide Y labelled neuropeptide Y receptors in rat forebrain membranes as a homogenous class of high-affinity sites. Between 80 and 85% of these receptors showed high affinity for Y1-selective antagonists such as (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine amide (BIBP3226). While competitive in functional studies
Benjamin Mirman et al.
Surgery, 168(1), 155-159 (2020-06-05)
Neuropeptide Y acts directly on the vasculature as a cotransmitter with norepinephrine for an augmented contraction. Little, however, is known about the effects of neuropeptide Y on the microvasculature of human skeletal muscle. Neuropeptide Y signaling has not been studied
Olga Zagorácz et al.
Brain research, 1727, 146563-146563 (2019-11-26)
Even though several of RFamide peptides have been shown to modify memory and learning processes in different species, almost nothing is known regarding cognitive effects of recently discovered neuropeptide QRFP. Considering multiple physiological functions of QRFP, localization of QRFP-synthesizing neurons
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