Pentagastrin is subject to oxidation in solution. A pentagastrin solution in DMF can be stored frozen to protect the TRP and MET from oxidation. Further protection from oxidation can be insured if the solution is prepared with degassed solvent and the solution is stored under an inert gas such as argon or dry nitrogen gas.
B1636
Pentagastrin
≥95% (HPLC), powder, CCK2 receptor agonist
Sinônimo(s):
Peptavlon, Petogasrin, N-t-Boc-β-Ala-Trp-Met-Asp-Phe amide
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About This Item
Fórmula empírica (Notação de Hill):
C37H49N7O9S
Número CAS:
Peso molecular:
767.89
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.
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Nome do produto
Pentagastrin, ≥95% (HPLC), powder
Ensaio
≥95% (HPLC)
Formulário
powder
condição de armazenamento
(Keep container tightly closed in a dry and well-ventilated place.)
cor
white to off-white
solubilidade
DMF: 20 mg/mL, clear, colorless to faint yellow or tan
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
CSCCC(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)CCNC(=O)OC(C)(C)C)C(=O)NC(CC(O)=O)C(=O)NC(Cc3ccccc3)C(N)=O
InChI
1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)
chave InChI
NEYNJQRKHLUJRU-UHFFFAOYSA-N
Informações sobre genes
mouse ... Cckbr(12426)
rat ... Cckar(24889) , Cckbr(25706)
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Amino Acid Sequence
Boc-Bal-Trp-Met-Asp-Phe-NH2
Descrição geral
Research area: Immunology & cytokines
Aplicação
Pentagastrin has been used to bidirectionally modulate lateral nucleus of the amygdala (LA) activity.[1] It has also been used as a cholecystokinin-2 receptor (CCK2R) agonist to block the receptor binding for Ga-DOTA-MGS5 in AR42J rat pancreatic cell lines during cell uptake and receptor binding studies.[2]
Ações bioquímicas/fisiológicas
Pentagastrin, a synthetic polypeptide is a gastrin analog. It contains the five C-terminal amino acids of gastrin.[3] It acts as a cholecystokinin-2 (CCK2) receptor/ cholecystokinin-B (CCKB) receptor agonist.[4] Pentagastrin stimulates the secretion of pepsin and gastric acid.[3] It also aids in the evaluation of gastric acid secretory function.[5] Pentagastrin exhibits panicogenic/ anxiogenic effects and thereby induces panic attacks in panic disorder (PD) patients.[4]
Inibidor
Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Certificados de análise (COA)
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Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus
Lee Y, et al.
Testing, 8(1), 203-203 (2017)
Makoto Inada et al.
Scandinavian journal of gastroenterology, 47(2), 148-154 (2012-01-05)
A traditional measurement of gastric acid, involving nasogastric intubation of stomach and acid suction, has been suggested as a gold standard. However, this causes the patient discomfort and cost increase, and is 'time-consuming'. A calcium [(13)C]carbonate (Ca(13)CO(3)) breath test was
Katsunori Iijima et al.
Journal of gastroenterology, 47(12), 1290-1297 (2012-05-03)
The association of Helicobacter pylori infection with aspirin-induced gastropathy is controversial. H. pylori infection exerts diverse effects on gastric acid secretion. In this study, the interaction between H. pylori infection and aspirin was investigated with reference to the individual gastric
Consistency of immigrant suicide rates in Austria with country-of-birth suicide rates: A role for genetic risk factors for suicide?
Voracek M, et al.
Psychiatry Research, 170(2-3), 286-289 (2009)
K McManus et al.
Journal of affective disorders, 66(2-3), 273-279 (2001-10-02)
Panic disorder (PD) symptomatology has been reported to be altered by hormonal events or treatments which affect estrogen levels. Coryell et al. [Arch. Gen. Psychiatry, 39 (1982) 701-703; Am. J. Psychiatry, 143 (1986) 508-510] have suggested that the increased cardiovascular
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How can Pentagastrin, Product B1636, solutions be stored?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the shelf-life of Pentagastrin, Product B1636?
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This product does not have any official shelf-life or expiration dating associated with it. The only date shown on the certificate of analysis will be the QC Release date. For customers whose systems require formal date management, use of a date one year from shipment is supported by our terms and conditions of supply.
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What is Pentagastrin, Product B1636, soluble in?
1 answer-
Pentagastrin is soluble in either dimethylformamide (DMF) or DMSO at a concentration of 20 mg/mL.
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