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A9202

Sigma-Aldrich

Angiotensin Fragment 1-7 acetate salt hydrate

≥90% (HPLC), powder, RAS heptapeptide

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About This Item

Fórmula empírica (Notação de Hill):
C41H62N12O11 · xC2H4O2 · yH2O
Peso molecular:
899.00 (anhydrous free base basis)
Número MDL:
MFCD00153513
Código UNSPSC:
12352202
ID de substância PubChem:
24891425
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

Angiotensin Fragment 1-7 acetate salt hydrate, ≥90% (HPLC), powder

Nível de qualidade

200

Ensaio

≥90% (HPLC)

Formulário

powder

nº de adesão UniProt

P01019

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O

InChI

1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)

chave InChI

PVHLMTREZMEJCG-UHFFFAOYSA-N

Informações sobre genes

human ... AGT(183)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro

Aplicação

Angiotensin Fragment 1-7 acetate salt hydrate has been used:
  • to evaluate its effects on a rat model of ventilator-induced diaphragmatic dysfunction (VIDD) with neuromuscular blocking agent infusion[1]
  • to unilaterally inject into the lateral preoptic area (LPA) to study its effects on intravesical pressure, arterial pressure, heart rate, and renal conductance in the female rats[2]
  • to study its association with influenza A virus (IAV) infection[3]

Ações bioquímicas/fisiológicas

Angiotensin fragment 1-7 is a biologically active heptapeptide of the renin-angiotensin system (RAS).[3] It is associated with anti-inflammatory and anti-fibrotic effects in many inflammatory diseases such as asthma, dyslipidemia, renal injury, arthritis, and lung fibrosis. Angiotensin fragment 1-7 acts as a pro-resolving mediator and induces resolution of inflammation via Mas receptor (MasR).[3] It is responsible for relaxation in several vascular beds. Angiotensin fragment 1-7 has a dual action of an angiotensin II type 1 (AT1) receptor agonist and antagonist depending on the presence of angiotensin II. It also serves as a substrate for angiotensin-converting enzyme (ACE). Sometimes, angiotensin fragment 1-7 prevents ACE activity leading to decreased angiotensin II generation and improved bradykinin-induced vasodilatation.[4]

Outras notas

Lyophilized from 0.5% acetic acid

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000325666
0000325666
0000251727
0000251728
0000251728

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Vanessa Zambelli et al.
Intensive care medicine experimental, 7(1), 8-8 (2019-01-20)
Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin system is involved in diaphragmatic skeletal muscle atrophy after MV. In particular, angiotensin-II can induce
Eliza M Melo et al.
Pharmacological research, 163, 105292-105292 (2020-11-11)
Resolution failure of exacerbated inflammation triggered by Influenza A virus (IAV) prevents return of pulmonary homeostasis and survival, especially when associated with secondary pneumococcal infection. Therapeutic strategies based on pro-resolving molecules have great potential against acute inflammatory diseases. Angiotensin-(1-7) [Ang-(1-7)]
S Y Osei et al.
European journal of pharmacology, 234(1), 35-42 (1993-03-30)
Regional vascular responses to angiotensin (Ang)-(1-7), a heptapeptide derivative of Ang II were investigated in the feline hindquarters and mesenteric vascular beds under conditions of controlled flow. In the mesenteric vascular bed, injections of Ang-(1-7) in doses of 1, 3
Joep H M van Esch et al.
European journal of pharmacology, 588(2-3), 286-293 (2008-05-31)
Aminopeptidases metabolize angiotensin II to angiotensin-(2-8) (=angiotensin III) and angiotensin-(3-8) (=angiotensin IV), and carboxypeptidases generate angiotensin-(1-7) from angiotensin I and II. Angiotensin-converting enzyme (ACE) inhibitors and/or angiotensin II type 1 (AT1) receptor blockers affect the concentrations of these metabolites, and
Gustavo B Lamy et al.
Frontiers in physiology, 12, 682711-682711 (2021-07-30)
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure in cats evokes
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Questions

  1. For how long can Angiotensin 1-7 (A9202) be stored at -20?

    1 answer

    1. This product is not assigned an expiration date. It contains a recommended retest date of approximately 5 years after the quality release date. A recommended retest date is the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.

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