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A6226

Sigma-Aldrich

AM251

>98% (HPLC), solid, cannabinoid receptor (CB1) antagonist

Sinônimo(s):

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide

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About This Item

Fórmula empírica (Notação de Hill):
C22H21N4OCl2I
Número CAS:
183232-66-8
Peso molecular:
555.24
Número MDL:
MFCD01861181
Código UNSPSC:
12352200
ID de substância PubChem:
24891069
NACRES:
NA.77

product name

AM251, >98% (HPLC), solid

Nível de qualidade

100

Ensaio

>98% (HPLC)

forma

solid

cor

white

solubilidade

DMSO: >10 mg/mL
H2O: insoluble

originador

Sanofi Aventis

cadeia de caracteres SMILES

Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4

InChI

1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)

chave InChI

BUZAJRPLUGXRAB-UHFFFAOYSA-N

Informações sobre genes

mouse ... Cnr1(12801) , Cnr2(12802)
rat ... Cnr1(25248)

Aplicação

AM251, a CB1 cannabinoid receptor antagonist, has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice.

Ações bioquímicas/fisiológicas

AM251 is a CB1 cannabinoid receptor antagonist.

Características e benefícios

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

Salt content may vary.

Frases de perigo

H413

Declarações de precaução

P273 - P501

Classificações de perigo

Aquatic Chronic 4

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

A8848

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