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A3021

Sigma-Aldrich

5-Aminosalicylic acid

95-98%, powder

Sinônimo(s):

5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine

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About This Item

Fórmula linear:
H2NC6H3-2-(OH)CO2H
Número CAS:
89-57-6
Peso molecular:
153.14
Beilstein:
2090421
Número CE:
201-919-1
Número MDL:
MFCD00007877
Código UNSPSC:
12352200

Ensaio

95-98%

forma

powder

cor

dark gray to brown

pf

275-280 °C (dec.) (lit.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Nc1ccc(O)c(c1)C(O)=O

InChI

1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11)

chave InChI

KBOPZPXVLCULAV-UHFFFAOYSA-N

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Aplicação

5-Aminosalicylic acid is a peroxidase substrate suitable for use in ELISA procedures. This substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. The reaction may be stopped with 3 N NaOH and read at 550 nm.

substituído por

Nº do produto
Descrição
Preços

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H317,H319,H335

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Krupa Shukla et al.
Bioorganic & medicinal chemistry letters, 21(20), 6184-6187 (2011-09-06)
A series of sulfasalazine analogs were synthesized and tested for their ability to block cystine-glutamate antiporter system xc⁻ using L-[(14)C]cystine as a substrate. Replacement of sulfasalazine's diazo group with an alkyne group led to an equally potent inhibitor, 2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)phenyl)ethynyl)benzoic acid
Virginie Andrzejak et al.
Bioorganic & medicinal chemistry, 19(12), 3777-3786 (2011-05-27)
Growing evidence suggests a role for the endocannabinoid (EC) system, in intestinal inflammation and compounds inhibiting anandamide degradation offer a promising therapeutic option for the treatment of inflammatory bowel diseases. In this paper, we report the first series of carboxamides
Suneela S Dhaneshwar et al.
European journal of medicinal chemistry, 44(1), 131-142 (2008-05-13)
Mutual amide prodrugs of 4-aminosalicylic acid with D-phenylalanine and L-tryptophan were synthesized for targeted drug delivery to the inflamed gut tissue in inflammatory bowel disease. Stability studies in aqueous buffers (pH 1.2 and 7.4) showed that the synthesized prodrugs were
Sung Jae Shin et al.
Antimicrobial agents and chemotherapy, 52(2), 418-426 (2007-12-12)
The in vitro susceptibility of human- and bovine-origin Mycobacterium paratuberculosis to the thioupurine drugs 6-mercaptopurine (6-MP) and azathioprine (AZA) was established using conventional plate counting methods and the MGIT 960 ParaTB culture system. Both 6-MP and AZA had antibacterial activity
Bryan Knuckley et al.
Bioorganic & medicinal chemistry, 16(2), 739-745 (2007-10-30)
Protein Arginine Deiminase 4 (PAD4) has emerged as a leading target for the development of a Rheumatoid Arthritis (RA) pharmaceutical. Herein, we describe the development of a novel screen for PAD4 inhibitors that is based on a PAD4-targeted Activity-Based Protein
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