A270
Anti-α1 Adrenergic Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinônimo(s):
Anti-ADRA1, Anti-ALPHA1BAR
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About This Item
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen ~60 kDa
reatividade de espécies
mouse, human, rat
técnica(s)
indirect immunofluorescence: 1:1,000 using mouse kidney distal tubule cells
western blot: 1:400
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
mouse ... Adra1d(11550)
rat ... Adra1d(29413)
Descrição geral
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three α1AR subtypes (α1A/D, α1B, and α1C), three α2ARs (α2A, α2B, and α2C), and three βAR subtypes (β1, β2, and β3). Adrenergic receptors participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
Adrenergic receptors are a G-protien coupled receptors that exist in two forms, α or β. Ligands for adrenergic receptors are catecholamines that induce a sympathetic response in animal cells.
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is human α1 adrenergic receptor subtype-specific and cross-reacts with rat and mouse α1 adrenergic receptor in immunoblotting. It detects α1 adrenergic receptor in mouse kidney membrane preparations by immunoblotting and stains plasma membrane of mouse kidney distal tubule cells in immunofluorescence.
Imunogênio
A270 is produced by immunizing New Zealand white rabbits with a synthetic peptide corresponding to aa residues 339-349 of human alpha 1a adrenergic receptor. This sequence is 100% conserved within the 3rd intracellular loop of all alpha1 adrenergic receptors. Peptide sequence: K339-F-S-R-E-K-K-A-A-K-T349
Aplicação
Rabbit polyclonal Anti-α1 Adrenergic Receptor antibody is used for the localization and detection of the α1 adrenergic receptor (~ 60 kDa). It can be used in immunoblotting and immunofluorescence techniques.
forma física
Solution in phosphate buffered saline containing 1 mg/ml BSA and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análise (COA)
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Julien Roche et al.
Sub-cellular biochemistry, 72, 261-278 (2015-07-16)
Defining the physical-chemical determinants of protein folding and stability, under normal and pathological conditions has constituted a major subfield in biophysical chemistry for over 50 years. Although a great deal of progress has been made in recent years towards this
X D Tang et al.
The Journal of general physiology, 117(3), 253-274 (2001-02-27)
Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca(2+)-activated K(+) channels (BK(Ca) or Slo)
Peter D Drummond et al.
Pain, 155(3), 606-616 (2013-12-18)
After peripheral nerve injury, nociceptive afferents acquire an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres. To investigate this in the present study, changes in α1-AR expression on nerve fibres
Mária Dux et al.
European journal of pain (London, England), 24(2), 383-397 (2019-10-30)
The α1 -adrenoceptor agonist, phenylephrine, is used at high concentrations as a mydriatic agent and for the treatment of nasal congestion. Among its adverse side-effects transient burning sensations are reported indicating activation of the trigeminal nociceptive system. Neuropeptide release, calcium
E S Drummond et al.
Neuroscience, 281, 99-109 (2014-10-01)
In certain forms of nerve injury and inflammation, noradrenaline augments pain via actions on up-regulated α1-adrenoceptors (α1-ARs). The aim of this study was to use immunohistochemistry to examine α1-AR expression on peripheral neurons, cutaneous blood vessels and keratinocytes after distal
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