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Documentos Principais

395R-1

Sigma-Aldrich

c-Myc (EP121) Rabbit Monoclonal Primary Antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100
500

conjugado

unconjugated

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

EP121, monoclonal

descrição

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulário

buffered aqueous solution

reatividade de espécies

human

embalagem

vial of 0.1 mL concentrate (395R-14)
vial of 0.5 mL concentrate (395R-15)
bottle of 1.0 mL predilute (395R-17)
vial of 1.0 mL concentrate (395R-16)
bottle of 7.0 mL predilute (395R-18)

fabricante/nome comercial

Cell Marque

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

Isotipo

IgG

controle

Burkitt lymphoma, prostate carcinoma

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

visualização

nuclear

Informações sobre genes

human ... MYC(4609)

Descrição geral

c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc isamplified in many different solid and hematopoietic tumors. Immunohistochemistry forc-Myc protein is used to identify the presence of a c-Myc translocation in various tumors,most frequently to aid in the diagnosis of Burkitt lymphoma.

Qualidade


IVD

IVD

IVD

RUO

Ligação

c-Myc Positive Control Slides, Product No. 395S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Christopher W Toon et al.
PloS one, 9(2), e87456-e87456 (2014-02-08)
MYC over-expression as determined by molecular means has been reported as a favorable prognostic biomarker in colorectal carcinoma (CRC). However MYC expression analysis is not available in the routine clinical setting. We investigated whether immunohistochemistry (IHC) for the myc protein
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
C V Dang
Molecular and cellular biology, 19(1), 1-11 (1998-12-22)
Rakesh Naidu et al.
International journal of molecular medicine, 9(2), 189-196 (2002-01-12)
Overexpression of c-myc protein and amplification of c-myc were investigated by immunohistochemistry and differential polymerase chain reaction (dPCR) in 440 formalin-fixed primary breast carcinoma tissues, respectively. Overexpression of c-myc was detected in 45% (199/440) and amplification of c-myc was observed
Bora Gurel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21(9), 1156-1167 (2008-06-24)
The MYC onco-protein is a transcription factor that regulates cell proliferation, metabolism, protein synthesis, mitochondrial function and stem cell renewal. A region on chromosome 8q24 encompassing the MYC locus is amplified in prostate cancer, but this occurs mostly in advanced
Tina Marie Green et al.
The American journal of surgical pathology, 36(4), 612-619 (2012-02-09)
Determining the presence of MYC gene rearrangements is becoming an increasingly important part of the diagnostic workup in aggressive lymphoma. Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. In addition, MYC aberrations are associated

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