226R-2

BCL2 (SP66) Rabbit Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: SP66, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• forma: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (226R-24); vial of 0.5 mL concentrate (226R-25); bottle of 1.0 mL predilute (226R-27); vial of 1.0 mL concentrate (226R-26); bottle of 7.0 mL predilute (226R-28)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotipo: IgG1
• controle: tonsil
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: cytoplasmic
• Informações sobre genes: human ... BCL2(596)

Descrição

Descrição geral

BCL2 is a protein associated with apoptosis regulation produced by the bcl-2 gene, located on chromosome 14q32. BCL2 is comprised of an alpha (239 amino acids) and beta chain. BCL2 (and thus BCL2 alpha chain) is found in mitochondrial and nuclear membranes and in the cytosol rather than the cell surface. In normal lymphoid tissue, BCL2 (and BCL2 alpha) antibody reacts with small B-lymphocytes in the mantle zone and many cells within the T-cell areas. Anti-BCL2 alpha has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in follicular lymphoma. This difference in staining pattern is not due to down regulation or decreased BCL2 mRNA, but largely to a post-translational mechanism with resultant decrease in protein levels. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymphoid lesions. Anti-BCL2 has been used as an indicator of minimal residual disease in the bone marrow of follicular lymphoma patients when staining is strong and uniform.

Ligação

BCL2 Positive Control Slides, Product No. 226S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable