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Documentos

Y0000705

Mirtazapine

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine

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About This Item

Fórmula empírica (Notação de Hill):
C17H19N3
Número CAS:
85650-52-8
Peso molecular:
265.35
Número MDL:
MFCD00865427
Código UNSPSC:
41116107
ID de substância PubChem:
329831107
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

mirtazapine

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

cadeia de caracteres SMILES

CN1CCN2C(C1)c3ccccc3Cc4cccnc24

InChI

1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

chave InChI

RONZAEMNMFQXRA-UHFFFAOYSA-N

Informações sobre genes

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HTR2A(3356) , HTR2C(3358)

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Mirtazapine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Ações bioquímicas/fisiológicas

Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H336

Classificações de perigo

Acute Tox. 4 Oral - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Michael Paulzen et al.
Psychopharmacology, 232(4), 807-813 (2014-08-26)
The aim of this study was to investigate the distribution pattern of mirtazapine and its metabolite normirtazapine (N-desmethylmirtazapine) in blood and cerebrospinal fluid (CSF). Concentrations of mirtazapine were measured in blood serum and CSF of 16 patients treated with daily
Hun Soo Chang et al.
Journal of clinical psychopharmacology, 34(4), 446-454 (2014-06-10)
We tested for the association of HTR1A and 5-HTT genetic polymorphisms with treatment response to mirtazapine and evaluated the interactive effect between the polymorphisms in 283 patients with major depressive disorder. Korean subjects with diagnosis of major depressive disorder using
Carolina Muguruza et al.
Neuropharmacology, 86, 311-318 (2014-08-26)
Several studies have demonstrated alterations in serotonin 5-HT2A (5-HT2AR) and glutamate metabotropic mGlu2 (mGlu2R) receptors in depression, but never in the same sample population. Recently it has been shown that both receptors form a functional receptor heterocomplex that is altered
Katarzyna Kamińska et al.
Pharmacological reports : PR, 66(6), 984-990 (2014-12-03)
The aim of our study was to understand the mechanism of clinical efficacy of the combination of an antidepressant and risperidone in drug-resistant depression. We studied the effect of an antidepressant (mirtazapine) and risperidone (atypical antipsychotic), given separately or jointly
Andrea de Bejczy et al.
Journal of clinical psychopharmacology, 35(1), 43-50 (2014-12-18)
The number of therapeutic drugs available for the treatment of alcohol use disorders (AUDs) is limited, and a well-tolerated, self-administrable drug is much needed. Subgroups of alcohol-dependent individuals, for example, individuals with heredity for AUD, may respond differently to pharmacological
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