PHR1702

Fluticasone Propionate

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinônimo(s): Fluticasone propionate, (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
• Fórmula empírica (Notação de Hill): C₂₅H₃₁F₃O₅S
• Número CAS: 80474-14-2
• Peso molecular: 500.57
• Número MDL: MFCD00866007
• Código UNSPSC: 41116107
• ID de substância PubChem: 329823565
• NACRES: NA.24

Propriedades

• grau: certified reference material; pharmaceutical secondary standard
• Nível de qualidade: 300
• Agency: traceable to BP 587; traceable to Ph. Eur. Y0000284; traceable to USP 1285873
• família API: fluticasone
• Certificado de análise (CofA): current certificate can be downloaded
• embalagem: pkg of 200 mg
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): pharmaceutical (small molecule)
• formato: neat
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)SCF
• InChI: 1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
• chave InChI: WMWTYOKRWGGJOA-CENSZEJFSA-N
• Informações sobre genes: human ... NR3C1(2908)

Descrição

Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Fluticasone Propionate, a neutral, highly potent trifluorinated corticosteroid, is a component of aqueous nasal sprays. It shows potent topical anti-inflammatory activity and is highly efficient in suppressing the nasal symptoms associated with rhinitis and asthma.

Aplicação

Fluticasone Propionate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Fluticasone propionate is a second generation glucocorticoid. Used as an anti-inflammatory agent for asthma. Shown to enhance eosinophil apoptosis in a concentration-dependent manner via the glucocorticoid receptor.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAB9941 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Warning
• Frases de perigo: H361f,H373
• Declarações de precaução: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Repr. 2 - STOT RE 2
• Órgãos-alvo: Endocrine system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable