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PHR1254

Supelco

Acyclovir

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Acycloguanosine, 9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir

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About This Item

Fórmula empírica (Notação de Hill):
C8H11N5O3
Número CAS:
Peso molecular:
225.20
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to BP 438
traceable to Ph. Eur. A0220000
traceable to USP 1012065

família API

acyclovir

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

NC1=Nc2c(ncn2COCCO)C(=O)N1

InChI

1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

chave InChI

MKUXAQIIEYXACX-UHFFFAOYSA-N

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acyclovir is an acyclic guanosine derivative effective in the treatment of skin infections caused by herpes simplex virus.

Aplicação

Acyclovir may be used as a pharmaceutical reference standard for the determination of the analyte in plasma, serum samples and bulk drug/formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC2956 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Certificados de análise (COA)

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Atenolol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1909

Atenolol

Simple spectrophotometric determination of acyclovir in bulk drug and formulations
Basavaiah K and Prameela HC
Il Farmaco (Societa Chimica Italiana : 1989), 57(6), 443-449 (2002)
Determination of acyclovir in human plasma by high-performance liquid chromatography
Boulieu R, et al
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(1), 233-236 (1997)
Determination of acyclovir in human serum by high-performance liquid chromatography using liquid--liquid extraction and its application in pharmacokinetic studies
Bahrami Gh, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 327-331 (2005)
Sonia Burrel et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 58(1), 321-324 (2013-06-05)
Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases
Monique van Velzen et al.
The Journal of infectious diseases, 208(9), 1359-1365 (2013-08-01)
Long-term acyclovir (ACV) prophylaxis, recommended to prevent recurrent herpes simplex virus type 1 (HSV-1) ocular disorders, may pose a risk for ACV-refractory disease due to ACV resistance. We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant

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