- Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.
Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2013-06-05)
Sonia Burrel, David Boutolleau, Georges Azar, Serge Doan, Claire Deback, Isabelle Cochereau, Henri Agut, Eric E Gabison
PMID23731845
RESUMO
Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases of ACV-resistant corneal HSV-1 in immunocompetent individuals with recurrent HK.