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Merck
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Documentos

P0847

Sigma-Aldrich

Piroxicam

meets USP testing specifications

Sinônimo(s):

4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide

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About This Item

Fórmula empírica (Notação de Hill):
C15H13N3O4S
Número CAS:
Peso molecular:
331.35
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.21

Agency

USP/NF
meets USP testing specifications

Nível de qualidade

forma

solid

aplicação(ões)

pharmaceutical (small molecule)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

chave InChI

QYSPLQLAKJAUJT-UHFFFAOYSA-N

Informações sobre genes

Procurando produtos similares? Visita Guia de comparação de produtos

Ações bioquímicas/fisiológicas

Cyclooxygenase inhibitor.

Pictogramas

Skull and crossbonesHealth hazard

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 3 Oral - STOT RE 2 Oral

Órgãos-alvo

Gastrointestinal tract

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Andres Lust et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 47-54 (2012-10-23)
The aim of this study was to gain understanding about the effects of different solid-state forms of a poorly water-soluble piroxicam on drug dissolution and oral bioavailability in rats. Three different solid-state forms of piroxicam were studied: anhydrate I (AH)
D Gerber
Drug intelligence & clinical pharmacy, 21(9), 707-710 (1987-09-01)
During the approximately five years (1981-86) that piroxicam has been available in South Africa, the Medicines Safety Centre has received 31 reports of adverse reactions associated with this drug. Among these are two reactions not previously recorded in the literature
Stéphane Lemaître et al.
Bioorganic & medicinal chemistry, 17(6), 2607-2622 (2009-03-06)
Based on the definition of a 5-HT(4) receptor antagonist pharmacophore, a series of pyrrolo[1,2-a]thieno[3,2-e] and pyrrolo[1,2-a]thieno[2,3-e] pyrazine derivatives were designed, prepared, and evaluated to determine the properties necessary for high-affinity binding to 5-HT(4) receptors. The compounds were synthesized by substituting
K Nezvalová-Henriksen et al.
BJOG : an international journal of obstetrics and gynaecology, 120(8), 948-959 (2013-03-16)
To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome. Cohort study. Norwegian population. A total of 90 417 women and singleton child pairs. The Norwegian Mother and Child Cohort Study and Medical Birth Registry of
José Marco-Contelles et al.
Journal of medicinal chemistry, 52(9), 2724-2732 (2009-04-21)
Tacripyrines (1-14) have been designed by combining an AChE inhibitor (tacrine) with a calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic strategy to confront AD. Tacripyrines are selective and potent AChE inhibitors in the nanomolar

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