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Documentos

H102

Supelco

Haloperidol metabolite II

analytical standard

Sinônimo(s):

(±)-4-(4-Chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol, Reduced Haloperidol

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About This Item

Fórmula empírica (Notação de Hill):
C21H25ClFNO2
Número CAS:
34104-67-1
Peso molecular:
377.88
Número MDL:
MFCD00055102
Código UNSPSC:
41116107
ID de substância PubChem:
329815151
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

cor

white

solubilidade

DMSO: 10 mg/mL

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

formato

neat

cadeia de caracteres SMILES

OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3

InChI

1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2

chave InChI

WNZBBTJFOIOEMP-UHFFFAOYSA-N

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000361578
0000361578
FN09271904
027M4605V
078K4619

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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

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H Hoja et al.
Journal of chromatography. B, Biomedical sciences and applications, 688(2), 275-280 (1997-01-24)
A sensitive and accurate liquid chromatographic-electrospray mass spectrometric (LC-ES-MS) method for the determination of haloperidol (H) and reduced haloperidol (RH) in human plasma is presented, using chlorohaloperidol as the internal standard. A 2-ml volume of plasma was subjected to basic
J G Shin et al.
British journal of clinical pharmacology, 51(1), 45-52 (2001-02-13)
We evaluated the inhibitory effect of haloperidol and its metabolites on CYP2D6 activity in order to better understand the potential role of these metabolites in drug interactions involving haloperidol. The inhibitory effects of haloperidol and five of its metabolites on
J M Leroux et al.
Progress in neuro-psychopharmacology & biological psychiatry, 18(2), 347-353 (1994-03-01)
1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient.
S Ulrich et al.
International clinical psychopharmacology, 14(4), 219-228 (1999-09-01)
The aim of this study was to investigate the effect of reduced haloperidol, the main metabolite of the antipsychotic drug haloperidol, on psychopathology improvement and extrapyramidal adverse effects in acute schizophrenia. The steady-state pharmacokinetics of reduced haloperidol was studied. Serum
K Mihara et al.
Therapeutic drug monitoring, 22(3), 245-249 (2000-06-13)
The effect of a genetic polymorphism of inducibility of cytochrome P450 (CYP) 1A2 on the steady state plasma concentrations (Css) of haloperidol and reduced haloperidol was studied to clarify if these Css are dependent on the CYP1A2 activity. The subjects
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