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Supelco

Crotalina

analytical standard

Sinônimo(s):

Monocrotalina

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About This Item

Fórmula empírica (Notação de Hill):
C16H23NO6
Número CAS:
315-22-0
Peso molecular:
325.36
Beilstein:
48732
Número MDL:
MFCD00084656
Código UNSPSC:
85151701
ID de substância PubChem:
329755589
NACRES:
NA.24

grau

analytical standard

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

pf

204 °C (dec.) (lit.)

aplicação(ões)

cleaning products
cosmetics
food and beverages
personal care

formato

neat

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@](C)(O)[C@](C)(O)[C@@H](C)C(=O)O3

InChI

1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

chave InChI

QVCMHGGNRFRMAD-XFGHUUIASA-N

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Descrição geral

Monocrotaline is a pyrrolizidine alkaloid that is found in plants, which belongs to the genus Crotalaria sp.

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Reconstituição

Dried down, 100 μg/mL after reconstitution with 1 mL of water

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Frases de perigo

H301,H351

Declarações de precaução

P201 - P301 + P310 + P330

Classificações de perigo

Acute Tox. 3 Oral - Carc. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number
BCBV7793
SZBF321XV
SZBE136XV
SZBB335XV

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Meijuan Tu et al.
Toxicology, 311(3), 225-230 (2013-07-09)
Monocrotaline (MCT) is a kind of toxic retronecine-type pyrrolizidine alkaloids (PAs) from plants of Crotalaria, which can be bio-activated by cytochrome P450 (CYP) enzymes in liver and then induce hepatotoxicity. Since CYPs are localized in the endoplasmic reticulum, the influx
Emmy Manders et al.
American journal of physiology. Lung cellular and molecular physiology, 303(12), L1070-L1078 (2012-09-11)
We previously demonstrated that diaphragm muscle weakness is present in experimental pulmonary arterial hypertension (PH). However, the nature of this diaphragm weakness is still unknown. Therefore, the aim of this study was to investigate whether changes at the sarcomeric level
Jose G Gomez-Arroyo et al.
American journal of physiology. Lung cellular and molecular physiology, 302(4), L363-L369 (2011-10-04)
Severe forms of pulmonary arterial hypertension (PAH) are characterized by various degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary vascular resistance and right ventricular afterload, thus contributing to the development of right ventricle dysfunction and failure.
Satoshi Matsuo et al.
The Journal of thoracic and cardiovascular surgery, 149(3), 902-909 (2014-12-03)
Lung ischemia-reperfusion (IR) injury during cardiopulmonary surgery is associated with postoperative morbidity and mortality, particularly in patients with pulmonary hypertension (PH). Using a rat model for monocrotaline-induced PH, we investigated the protective effect of rosuvastatin against IR injury in lungs
Jolyane Meloche et al.
Journal of the American Heart Association, 2(1), e005157-e005157 (2013-03-26)
Pulmonary arterial hypertension (PAH) is a vasculopathy characterized by enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and suppressed apoptosis. This results in both increase in pulmonary arterial pressure and pulmonary vascular resistance. Recent studies have shown the implication of
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