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MABF31

Sigma-Aldrich

Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8

clone 8C8, from mouse

Sinônimo(s):

defensin, alpha 5, Paneth cell-specific, defensin, alpha 5, preproprotein, defensin-5, defensin 5, Defensin, alpha 5

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

8C8, monoclonal

reatividade de espécies

human

técnica(s)

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG2bκ

nº de adesão NCBI

NP_066290

nº de adesão UniProt

Q01523

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... DEFA5(1670)

Descrição geral

Human alpha defensin-5 (HD5) is one of six peptides belonging to the alpha defensin family. Defensins are small peptides involved in immunological defense against viral and microbial infections through either direct interaction with pathogens or in combination with other immune system factors. There are three subfamilies of defensins (α, β, and θ). α defensins are only observed in mammals and are mainly β-sheet structures. Alpha defensin-5 (HD5) is primarily expressed in the Paneth cells found within the small intestine, and has been shown to possess activity against both Gram-positive and Gram-negative microbes. Studies have shown alpha defensin-5 (HD5) to be a strong antagonist towards human Papillomavirus infection. It may also play a role Crohn’s disease.

Imunogênio

Recombinant protein corresponding to human alpha defensin-5 (HD5).

Aplicação

Anti-Alpha Defensin-5 (HD5) Antibody, clone 8C8 detects level of Alpha Defensin-5 (HD5) & has been published & validated for use in IH & WB.
Western Blot Analysis: 0.5 ug/mL from a previous lot detected alpha defensin-5 (HD5) in human small intestine tissue lysate. The urea-treated method is recommended instead of SDS page (Shen, B. et al., 2005).

Qualidade

Evaluated by Immunohistochemistry in normal human tranverse colon tissue.

Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected alpha defensin-5 (HD5) in normal human tranverse colon tissue.

Descrição-alvo

10 kDa calculated

forma física

Format: Purified

Nota de análise

Control
Normal human tranverse colon tissue

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Charles Vragniau et al.
Journal of virology, 91(6) (2017-01-13)
Defensins are small antimicrobial peptides capable of neutralizing human adenovirus (HAdV) in vitro by binding capsid proteins and blocking endosomal escape of virus. In humans, the alpha defensin HD5 is produced by specialized epithelial cells of the gastrointestinal and genito-urinary
Fardou H Heida et al.
Pediatric research, 80(2), 306-310 (2016-04-07)
Little is known about the perinatal development of Paneth cells (PCs) during gestation and the relation with necrotizing enterocolitis (NEC). We aimed to investigate when PCs arise and when they become immune competent during gestation. We included 57 samples of
Gaelle Noel et al.
Frontiers in cell and developmental biology, 9, 685171-685171 (2021-07-31)
Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cellular events involved in these

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