MAB5328
Anti-RAGE Antibody, clone DD/A11 or A11
Chemicon®, from mouse
Sinônimo(s):
Receptor for Advanced Glycosylation End Products.
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified antibody
tipo de produto de anticorpo
primary antibodies
clone
DD/A11, monoclonal
mAbA11, monoclonal
reatividade de espécies
human, bovine, mouse
reatividade da espécie (prevista por homologia)
rat
fabricante/nome comercial
Chemicon®
técnica(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Isotipo
IgG2a
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
modificação pós-traducional do alvo
glycosylation
Informações sobre genes
human ... AGER(177)
Descrição geral
RAGE (Receptor for Advanced Glycosylation End Products) is a 35 kDa cell surface receptor that binds molecules modified by advanced glycation end products (AGEs), an irreversible non-enzymatic reaction occuring from the interaction of proteins and lipids with glucose. The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. AGE/RAGE accumulates at sites of vascular disease in diabetes, but blockade of RAGE suppresses development of atherosclerosis and vascular disorders. RAGE binds to amyloid beta, which is overproduced in neurons and vessels in Alzheimer′s disease, and this interaction results in oxidative stress leading to neuronal degeneration.
Especificidade
RAGE (Receptor for Advanced Glycosylated End Products). The antibody recognizes both natural and recombinant RAGE.
Imunogênio
Recombinant truncated extracellular part of RAGE produced in E. coli.
Aplicação
Anti-RAGE Antibody, clone DD/A11 or A11 is an antibody against RAGE for use in ELISA, IC, IH & WB.
Immunohistochemistry:
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.
Immunocytochemistry:
A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.
ELISA:
A previous lot was shown to work on direct ELISA.
Immunoblotting:
Recognizes a band of ~48kDa in bovine lung extract.
Optimal working dilutions must be determined by end user.
Qualidade
Routinely evaluated by Western Blot on Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
Western Blot:
1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates.
Descrição-alvo
48 kDa
forma física
Format: Purified
Purified mouse monoclonal IgG2a in buffer containing 0.02 M phosphate buffer, 0.25 M NaCl, and 0.1% sodium azide.
Nota de análise
Control
Lung tissue, mouse brain lysate.
Lung tissue, mouse brain lysate.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Anna Kamynina et al.
Journal of cellular physiology, 236(9), 6496-6506 (2021-02-12)
The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and β-amyloid. However, most
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.
Loeser, RF; Yammani, RR; Carlson, CS; Chen, H; Cole, A; Im, HJ; Bursch, LS; Yan, SD
Arthritis and Rheumatism null
Atsushi Fujiya et al.
Obesity (Silver Spring, Md.), 22(2), 371-379 (2013-06-28)
The S100 calcium binding protein B (S100B) implicated in brain inflammation acts via the receptor of advanced glycation end products (RAGE) and is also secreted from adipocytes. We investigated the role of S100B in the interaction between adipocytes and macrophages
Gareth D Healey et al.
Journal for immunotherapy of cancer, 7(1), 280-280 (2019-10-31)
The treatment of endometrial cancer (EC), the most common gynecological cancer, is currently hampered by the toxicity of current cytotoxic agents, meaning novel therapeutic approaches are urgently required. A cohort of 161 patients was evaluated for the expression of the
Philipp Ehlermann et al.
Cardiovascular diabetology, 5, 6-6 (2006-04-01)
Atherosclerosis is an inflammatory disease in which a perpetuated activation of NFkappaB via the RAGE (receptor for advanced glycation end products)-MAPK signalling pathway may play an important pathogenetic role. As recently S100 proteins have been identified as ligands of RAGE
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