Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos

MAB1820

Sigma-Aldrich

Anti-Scribble Antibody

clone 7C6.D10, Chemicon®, from mouse

Sinônimo(s):

Scrib, LAP4

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

7C6.D10, monoclonal

reatividade de espécies

human

fabricante/nome comercial

Chemicon®

técnica(s)

western blot: suitable

Isotipo

IgG1κ

nº de adesão GenBank

AAL38976

nº de adesão UniProt

Q14160

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SCRIB(23513)

Descrição geral

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Especificidade

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Imunogênio

Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Aplicação

Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers

Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Qualidade

Routinely evaluated by Western blot on HeLa cell lysates.

Descrição-alvo

220 kDa

forma física

Format: Purified
Purified in PBS containing with 0.05% NaN3.

Armazenamento e estabilidade

Maintain at 2-8°C for up to 1 year after date of receipt.

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações legais

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services

Not finding the right product?  

Try our Ferramenta de seleção de produtos.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum
Sang Joon Won et al.
ACS chemical biology, 13(6), 1560-1568 (2018-05-08)
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity proteins, and G proteins as rapidly cycling S-palmitoylated proteins sensitive

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica