ABC342

Anti-KPNA2 Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Karyopherin alpha nucleoprotein interactor 2, Importin alpha2, IPOA1, RAG cohort protein 1, QIP2, Karyopherin subunit alpha-2, SRP1-alpha
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: rat, human
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• nº de adesão UniProt: P52292
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... KPNA2(3838)

Descrição

Descrição geral

Karyopherin alpha nucleoprotein interactor 2 (KPNA2), also known as Importin alpha-2, RAG cohort protein 1 (RCH1), SRP1-alpha QIP2 (SRP1), is the alpha subunit 2 of karyopherin which functions as a cargo carrier that transports various complexes from cytoplasm into nucleus and forms a complex with importin subunit beta-1 and. KPNA2 is expressed ubiquitously and contains one IBB/importin beta domain, ten Armadillo repeats and three intervening nuclear localization sequences (NLSs). Recent studies have shown that KPNA2 plays an important role in tumorigenesis and tumor progression. KPNA2 is a heterodimer with KPNB1. It has been implied to interact with HIV-1 Vpr, PLAG1, ANP32E, ARL4A, CTNNBL1, NBN and APEX1 (via N-terminus). KPNA2 is also a component of a complex containing CSE1L, RAN and KPNA2 and interacts directly with CSE1L.

Imunogênio

KLH-conjugated linear peptide corresponding to human KPNA2.

Aplicação

Detect Importin using this rabbit polyclonal antibody, Anti-KPNA2 Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected KPNA2 in human heart tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Qualidade

Evaluated by Western Blotting in rat heart tissue lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected KPNA2 in 15 µg of rat heart tissue lysate.

Descrição-alvo

~55 kDa observed. Uncharacterized bands may appear in some lysate(s).

forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Armazenamento e estabilidade

Stable for 1 year at 2-8°C from date of receipt.

Nota de análise

Control
Rat heart tissue lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable