8.51085

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Sinônimo(s): COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
• Fórmula empírica (Notação de Hill): C₁₂H₁₉F₆N₄O₄P
• Número CAS: 1075198-30-9
• Peso molecular: 428.27
• Número MDL: MFCD11975052
• Código UNSPSC: 12352107
• NACRES: NA.22

Propriedades

• Nome do produto: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem^®
• Nível de qualidade: 300
• linha de produto: Novabiochem^®
• Ensaio: ≥99.0% (HPLC)
• Formulário: powder
• adequação da reação: reaction type: Coupling Reactions
• fabricante/nome comercial: Novabiochem^®
• pf: >140 °C
• aplicação(ões): peptide synthesis
• temperatura de armazenamento: 15-25°C
• cadeia de caracteres SMILES: F[P-](F)(F)(F)(F)F.N1(CCOCC1)C(=[O+]\N=C(/C(=O)OCC)\C#N)N(C)C
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• chave InChI: GPDHNZNLPKYHCN-DZOOLQPHSA-N

Descrição

Descrição geral

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU ^[1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
^[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
^[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

Aplicação

• Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

Nota de análise

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable