8.22278

Acetic anhydride

for synthesis

• Sinônimo(s): Acetic anhydride, Acetyl acetate, Acetyl oxide
• Fórmula linear: (CH₃CO)₂O
• Número CAS: 108-24-7
• Peso molecular: 102.09
• Número MDL: MFCD00008705
• Código UNSPSC: 12352106
• Número do índice EC: 203-564-8
• NACRES: NA.22

Propriedades

• pressão de vapor: 4 hPa ( 20 °C)
• Nível de qualidade: 200
• Ensaio: ≥98.0% (GC)
• forma: liquid
• temperatura de autoignição: 330 °C
• potência: 630 mg/kg LD₅₀, oral (Rat); 4320 mg/kg LD₅₀, skin (Rabbit)
• Lim. expl.: 2.0-10.2 % (v/v)
• pH: 3 (20 °C, 10 g/L in H₂O)
• pf: -73 °C
• temperatura de transição: flash point 49 °C
• densidade: 1.08 g/cm³ at 20 °C
• temperatura de armazenamento: 2-30°C
• InChI: 1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
• chave InChI: WFDIJRYMOXRFFG-UHFFFAOYSA-N

Descrição

Descrição geral

Acetic anhydride is a widely used reagent in organic synthesis. The reagent is effective for acetylating alcohols, amines, and thiols. Additionally, it is used in various named reactions such as the Pummerer reaction, the Perkin reaction, the Polonovski reaction, the N-oxide reaction, and the Thiele reaction. Acetic anhydride is an effective reagent during oxidation of alcohols, dehydration, ether cleavage, enol acetate formation, and gem-diacetate formation.

Aplicação

Acetic anhydride is used:

• In the solvent free acylation of 2-methylfuran to 2-acetyl-5-methylfuran in presence of hydroxide fluorides catalyst.
• As a catalyst in the synthesis of 3-arylideneisobenzofuran-1(3H)-one derivatives from phthalic anhydride and quinoline derivatives.
• In the preparation of hyperbranched poly ethoxy siloxanes by condensation reaction with tetra ethoxy silane in presence of an organotitanium catalyst.

Nota de análise

Assay (GC, area%): ≥ 98.0 % (a/a)
Density (d 20 °C/ 4 °C): 1.080 - 1.082
Identity (IR): passes test

Informações de segurança

• Pictogramas: GHS02,GHS05,GHS06
• Palavra indicadora: Danger
• Frases de perigo: H226 - H302 - H314 - H330
• Declarações de precaução: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classificações de perigo: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Código de classe de armazenamento: 3 - Flammable liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 120.2 °F - closed cup
• Ponto de fulgor (°C): 49 °C - closed cup