658548

AG 1478

InSolution, ≥98%, inhibitor EGF receptor tyrosine kinase

• Sinônimo(s): InSolution AG 1478
• Fórmula empírica (Notação de Hill): C₁₆H₁₄ClN₃O₂
• Número CAS: 175178-82-2
• Peso molecular: 315.75
• Número MDL: MFCD00270914
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: liquid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: clearfaint tan
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• chave InChI: GFNNBHLJANVSQV-UHFFFAOYSA-N

Descrição

Descrição geral

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC₅₀ = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC₅₀ >100 µM), the platelet-derived growth factor (PDGF) receptor (IC₅₀ >100 µM), and p210^Bcr-Abl (IC₅₀ >50 µM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
Epidermal growth factor receptor kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 3 nM against of epidermal growth factor receptor kinase

Embalagem

Packaged under inert gas

Advertência

Toxicity: Irritant (B)

forma física

A 10 mM (1 mg/317 µl) solution of AG 1478 (Cat. No. 658552) in DMSO.

Reconstituição

Following initial thaw, aliquot and freeze (-20°C).

Outras notas

Levitski, A., and Gazit, A. 1995. Science267, 1782.
Fry, D.W., et al. 1994. Science265, 1093.
Osherov, N., and Levitski, A. 1994. Eur. J. Biochem.225, 1047.
Ward, W.H., et al. 1994. Biochem. Pharmacol. 48, 659.

Informações legais

Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Ponto de fulgor (°C): 87 °C - closed cup - (Dimethylsulfoxide)