654380

Tunicamycin

from Strepomyces lysosuperficus, ≥98% (A+B+C+D, HPLC), powder, N-acetylglucosamine transferase, Calbiochem

• Sinônimo(s): Tunicamycin, Streptomyces lysosuperficus
• Fórmula empírica (Notação de Hill): C₃₉H₆₄N₄O₁₆
• Número CAS: 11089-65-9
• Peso molecular: 844.94
• Número MDL: MFCD00065709
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• product name: Tunicamycin, Streptomyces lysosuperficus,
• descrição: Tunicamycin, Streptomyces lysosuperficus
• Nível de qualidade: 200
• Ensaio: ≥98% (A+B+C+D, HPLC)
• forma: powder
• fabricante/nome comercial: Calbiochem^®
• solubilidade: DMSO: 10 mg/mL; DMF: soluble; pyridine: soluble
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1
• chave InChI: ZHSGGJXRNHWHRS-PEALBESXSA-N

Descrição

Descrição geral

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).

A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells.

Ações bioquímicas/fisiológicas

Primary Target
N-linked glycosylation

Secondary Target
thrombin-induced Ca²⁺ mobilization in cells

Advertência

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Nota de preparo

Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.

Reconstituição

Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857.
Price, B.D., et al. 1992. J. Cell Physiol.152, 545.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 1 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable